Othman N H, Othman M S, Ismail A N, Mohammad N Z, Ismail Z
Department of Pathology, Universiti Sains Malaysia, Malaysia.
Aust N Z J Obstet Gynaecol. 1996 May;36(2):216-8. doi: 10.1111/j.1479-828x.1996.tb03291.x.
A 30-year old female who initially had typical endometriosis treated according to a standard regimen later developed numerous highly vascular endometrial polyps on the vagina, cervix, ureter, serosal surfaces of the uterus, pouch of Douglas (POD) and other areas of pelvic peritoneum as well as the endometrium 8 months after withdrawal of treatment with Zoladex gonadotrophin releasing hormone (GnRH) agonist used for treatment of this disease. We postulate that these polyps developed as a rebound phenomenon upon withdrawal of Zoladex. We believe this is the first report of this complication following use of GnRH analogue.
一名30岁女性，最初患有典型子宫内膜异位症，按标准方案治疗，在使用用于治疗该疾病的诺雷德促性腺激素释放激素（GnRH）激动剂治疗停药8个月后，阴道、宫颈、输尿管、子宫浆膜面、道格拉斯窝（POD）及盆腔腹膜其他区域以及子宫内膜出现大量高血管性子宫内膜息肉。我们推测这些息肉是在停用诺雷德后作为一种反弹现象出现的。我们认为这是使用GnRH类似物后出现这种并发症的首例报告。
