Department of Psychiatry, University of Michigan, Ann Arbor, MI.
J ECT. 2011 Jun;27(2):168-74. doi: 10.1097/YCT.0b013e3181f665e4.
Retrospective data are presented for 6 adolescents ranging in age from 14 to 17 years, who were diagnosed with severe treatment-resistant major depression (TRD). Subjects were treated with one or more index courses of electroconvulsive therapy (ECT) followed by continuation ECT (C-ECT, up to 6 months of ECT) or maintenance ECT (M-ECT; ECT beyond 6 months) when necessary. Electroconvulsive therapy was continued until remission or until minimal residual symptoms were evident. Pharmacotherapy and psychotherapy were reintroduced during C-ECT or M-ECT. Premorbid functioning was achieved by 5 of 6 cases. Cognitive deficits were not evident. In fact, comparison of pre-ECT and post-ECT neuropsychological functioning revealed a trend toward improved auditory and verbal memory on most of the results. We concluded that C-ECT and M-ECT are useful and safe treatment strategies for selected adolescents with severe treatment-resistant depression, and symptom remission may be achieved without experiencing cognitive impairment.
回顾性数据显示，6 名年龄在 14 至 17 岁之间的青少年被诊断为严重的治疗抵抗性重度抑郁症（TRD）。这些患者接受了一次或多次电惊厥治疗（ECT）作为起始治疗，随后进行延续性 ECT（C-ECT，ECT 治疗持续 6 个月）或维持性 ECT（M-ECT；ECT 治疗持续 6 个月以上），如果需要的话。ECT 治疗一直持续到缓解或出现最小残留症状为止。在 C-ECT 或 M-ECT 期间重新引入药物治疗和心理治疗。6 例中有 5 例恢复了病前的功能。认知缺陷不明显。事实上，与 ECT 前后的神经心理学功能比较显示，大多数结果中听觉和语言记忆的趋势有所改善。我们得出结论，C-ECT 和 M-ECT 是治疗严重治疗抵抗性抑郁症的青少年的有效和安全的治疗策略，并且可以在不出现认知障碍的情况下实现症状缓解。
