老年人的多种药物治疗：老年人的药物反应和相互作用。
Polypharmacy in the Elderly: Drug reactions and interaction in the aged.
出版信息
Can Fam Physician. 1991 Jan;37:120-4.
Abstract
The elderly tolerate smaller doses of most drugs, largely because changes in body fat content, water content, and muscle mass often lead to higher blood levels than in a young person of the same weight. Moreover, diminished renal blood flow and creatinine clearance decrease excretion of agents cleared by the kidney. This leads to an increased number of drug reactions and interactions and consequent hospital admissions.
摘要
老年人对大多数药物的耐受剂量较小，主要是因为体内脂肪含量、水分含量和肌肉质量的变化往往导致血液水平高于相同体重的年轻人。此外，肾血流量和肌酐清除率降低会减少通过肾脏清除的药物的排泄。这导致药物反应和相互作用的增加，进而导致住院。
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本文引用的文献
1
Ethanol potentiation of aspirin-induced prolongation of the bleeding time.乙醇对阿司匹林所致出血时间延长的增强作用。
N Engl J Med. 1982 Apr 8;306(14):852-4. doi: 10.1056/NEJM198204083061406.
2
Drug therapy: nonsteroidal antiinflammatory drugs (first of two parts).药物治疗：非甾体抗炎药（两部分中的第一部分）
N Engl J Med. 1980 May 22;302(21):1179-85. doi: 10.1056/NEJM198005223022105.
3
Age-related morphine kinetics.与年龄相关的吗啡动力学。
Clin Pharmacol Ther. 1983 Sep;34(3):364-8. doi: 10.1038/clpt.1983.180.
4
Diazepam impairs performance in normal elderly subjects.地西泮会损害正常老年受试者的表现。
Psychopharmacol Bull. 1984 Winter;20(1):137-9.
5
Complications of alcohol use combined with drug therapy in the elderly.老年人酒精使用与药物治疗相结合的并发症。
J Am Geriatr Soc. 1982 Nov;30(11 Suppl):S88-93. doi: 10.1111/j.1532-5415.1982.tb01362.x.
6
Intensive hospital monitoring of adverse reactions to drugs.医院对药物不良反应进行强化监测。
Br Med J. 1969 Mar 1;1(5643):531-6. doi: 10.1136/bmj.1.5643.531.
7
Inhibition of drug metabolism by acute ethanol intoxication. A hepatic microsomal mechanism.急性乙醇中毒对药物代谢的抑制作用。一种肝微粒体机制。
Am J Med. 1970 Dec;49(6):801-6. doi: 10.1016/s0002-9343(70)80061-4.
8
Aging, alcohol, and the liver.衰老、酒精与肝脏。
J Am Geriatr Soc. 1988 Mar;36(3):255-65. doi: 10.1111/j.1532-5415.1988.tb01810.x.
9
Prescribing for the elderly. Part I: Sensitivity of the elderly to adverse drug reactions.老年人用药。第一部分：老年人对药物不良反应的敏感性。
J Am Geriatr Soc. 1988 Feb;36(2):142-9. doi: 10.1111/j.1532-5415.1988.tb01785.x.
10
Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons.老年人使用非甾体抗炎药与消化性溃疡死亡
Ann Intern Med. 1988 Sep 1;109(5):359-63. doi: 10.7326/0003-4819-109-5-359.
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