医院对药物不良反应进行强化监测。
Intensive hospital monitoring of adverse reactions to drugs.
作者信息
Hurwitz N, Wade O L
出版信息
Br Med J. 1969 Mar 1;1(5643):531-6. doi: 10.1136/bmj.1.5643.531.
Abstract
A total of 1,268 patients admitted to hospital wards were kept under surveillance by one observer throughout their stay in hospital. All drugs given to them and the occurrence of adverse reactions were recorded.Drug reactions were found in 10.2% of the 1,160 patients who received drug therapy. Most reactions were due to known pharmacological actions of the drugs. Though only four reactions were of life-threatening seriousness, 80% of the 129 reactions observed were of moderate severity. Digitalis preparations, bronchodilator drugs, and ampicillin had the highest reaction rates. It is suggested that larger surveys of adverse reactions in relation to drug usage would make a useful contribution to the problem.
摘要
共有1268名住院患者在住院期间由一名观察者全程进行监测。记录了给予他们的所有药物以及不良反应的发生情况。在接受药物治疗的1160名患者中，有10.2%出现了药物反应。大多数反应是由药物已知的药理作用引起的。虽然只有4例反应具有危及生命的严重性，但在观察到的129例反应中，80%为中度严重程度。洋地黄制剂、支气管扩张剂药物和氨苄青霉素的反应率最高。有人建议，针对药物使用情况进行更大规模的不良反应调查将对解决这一问题做出有益贡献。
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