Klittich L, Lehr H J, Schmidt-Elmendorff H, Steyer M
Geburtshilfe Frauenheilkd. 1978 Oct;38(10):831-9.
20 girls, their age being between 8 to 13 years, with an actual height above the 97th percentile received 10,0 mg conjugated estrogens per day cyclicly or 0,3 mg ethinylestradiol continuously over a period of 0,3 to 3,8 years, in order to inhibit excessive growth. The duration of therapy ranged from 0,6 to 3,8 years regularly. Before and during treatment the patients were examined, and each time the expected final height was calculated based on the actual height and the bone age. The stage of puberty was defined according to Blizzard, and the determination of the bone age was performed as described by Tanner and Whitehouse. The extragenital side effects were also recorded. The effectiveness of the estrogen treatment, i. e. the reduction of the expected final height, depends on the chronological age, the skeletal age and the stage of puberty before therapy. It ranged between 0,5 and 5,1 cm. The earlier treatment was started the better were the results. The effectiveness was more obvious in cases with continuous estrogen treatment. No serious side effects could be observed.
20名年龄在8至13岁之间、实际身高超过第97百分位数的女孩,为抑制生长过快,每天周期性服用10.0毫克结合雌激素,或连续服用0.3毫克炔雌醇,为期0.3至3.8年。治疗持续时间有规律地在0.6至3.8年之间。在治疗前和治疗期间对患者进行检查,每次根据实际身高和骨龄计算预期最终身高。青春期阶段根据布莱兹德标准定义,骨龄测定按照坦纳和怀特豪斯所述方法进行。还记录了生殖器外副作用。雌激素治疗的有效性,即预期最终身高的降低,取决于治疗前的实际年龄、骨骼年龄和青春期阶段。降低幅度在0.5至5.1厘米之间。治疗开始得越早,效果越好。连续雌激素治疗的病例效果更明显。未观察到严重副作用。