Andreeva T V, Vereshagin E I, Ermakova N N, Madonov P G, Pershina O V, Skurikhin E G, Zjuzkov G N, Minakova M Ju, Khmelevskaya E S, Dygai A M
Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2010 Oct;149(4):421-4. doi: 10.1007/s10517-010-0960-x.
Neuroprotective activity of immobilized granulocyte CSF (nanotechnology with electron-beam synthesis) and hyaluronidase was studied on the model of posthypoxic encephalopathy. Oral administration of immobilized granulocyte CSF had no effect on manifestations of posthypoxic psychoneurological disorders in animals. Combined treatment with immobilized granulocyte CSF and hyaluronidase prevented impairment of orientation and exploratory behavior and development of amnesia in mice with hypoxic injury.
