Department of Nutrition, Federal University of Teresina, Piaui, Brazil.
Int J Vitam Nutr Res. 2010 Jun;80(3):188-96. doi: 10.1024/0300-9831/a000017.
BACKGROUND & AIMS: To investigate the effect of vitamin A supplementation on parameters of the immune system of vitamin A-deficient children.
The study was carried out in four phases: 1) determination of serum retinol in 631 children from 36 to 83 months of age; 2) assessment of immunological markers [immunoglobulins and complement fractions, immunophenotyping of T and B lymphocytes, and natural killer (NK) cells], blood count, and serum ferritin of 52 vitamin A-deficient children (serum retinol < 0.70 micromol/L); 3) supplementation of the 52 deficient children with 200,000 IU of vitamin A; 4) determination of serum retinol and the immunological parameters 2 months after vitamin A supplementation.
before vitamin A supplementation, 24.0 % of the children were anemic and 4.3 %had reduced ferritin concentrations. There was no significant difference between mean values of retinol according to the presence/absence of anemia. The mean values of the humoral and cellular immunological parameters did not show a statistically significant difference before and after supplementation with vitamin A. Children with concomitant hypovitaminosis A and anemia presented a significant increase in absolute CD4 and CD8 T-cell counts after vitamin A supplementation (p < 0.05).
vitamin A had an effect on the recruitment of T and B lymphocytes to the circulation of children with hypovitaminosis A and anemia.
研究维生素 A 补充对维生素 A 缺乏儿童免疫系统参数的影响。
该研究分四个阶段进行：1）检测 631 名 36 至 83 个月大儿童的血清视黄醇；2）评估免疫标志物[免疫球蛋白和补体片段、T 和 B 淋巴细胞免疫表型以及自然杀伤（NK）细胞]、血细胞计数和血清铁蛋白，研究对象为 52 名维生素 A 缺乏儿童（血清视黄醇<0.70 μmol/L）；3）对 52 名缺乏维生素 A 的儿童补充 200,000IU 维生素 A；4）在维生素 A 补充 2 个月后，检测血清视黄醇和免疫参数。
在进行维生素 A 补充之前，24.0%的儿童贫血，4.3%的儿童铁蛋白浓度降低。贫血组和非贫血组的视黄醇平均值之间没有显著差异。在补充维生素 A 前后，体液和细胞免疫参数的平均值没有显示出统计学上的显著差异。同时伴有维生素 A 缺乏和贫血的儿童在补充维生素 A 后，绝对 CD4 和 CD8 T 细胞计数显著增加（p<0.05）。
维生素 A 对维生素 A 缺乏和贫血儿童的 T 和 B 淋巴细胞向循环系统的募集有影响。
