维生素A缺乏对胸腺素-β4和CD4浓度的影响。

Effect of vitamin A deficiency on thymosin-β4 and CD4 concentrations.

作者信息

El-Zayat Salwa Refat, Sibaii Hiba, Mahfouz Nermine N, Sallam Sara F, Fahmy Reham F, Abd El-Shaheed Azza

机构信息

Medical Physiology Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki POB:12311, Cairo, Egypt.

Child Health Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt.

出版信息

J Genet Eng Biotechnol. 2018 Jun;16(1):57-61. doi: 10.1016/j.jgeb.2017.10.007. Epub 2017 Oct 10.

DOI:10.1016/j.jgeb.2017.10.007

PMID:30647705

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6296595/

Abstract

Vitamins are evaluated for their role in immunity. Recently, vitamin A received a particular attention as a critical micronutrient for regulating immune system. Therefore, the present study aimed to search for new about vitamin A. Forty-eight Egyptian adults aged from 18 to 42 years old from both sexes were subjected to clinical examination and nutrition questionnaire and were screened for vitamin A by using ELISA method. Forty subjects were selected and subdivided into two groups. Group 1 with vitamin A at level >200 µg/dl consists of 10 healthy subjects. Group 2 with vitamin A deficiency at level <50 µg/dl consists of 30 subjects. Tβ4 and CD4 levels were also determined by a commercial ELISA kit. Results showed a significant decrease in serum levels of Tβ4 and CD4 in group 2 than group 1 at P < .003 and P < .019 respectively. Both of Tβ4 and CD4 had positive correlation with vitamin A level at P < .000 and P < .003 respectively as well as with each other at p < .000. We concluded that vitamin A deficiency may be influence the levels of Tβ4 and CD4.

摘要

维生素因其在免疫中的作用而受到评估。最近，维生素A作为调节免疫系统的关键微量营养素受到了特别关注。因此，本研究旨在探寻有关维生素A的新信息。对48名年龄在18至42岁之间的埃及成年人（男女均有）进行了临床检查和营养问卷调查，并采用酶联免疫吸附测定（ELISA）法对其维生素A水平进行了筛查。选取了40名受试者并将其分为两组。第1组维生素A水平>200μg/dl，由10名健康受试者组成。第2组维生素A缺乏，水平<50μg/dl，由30名受试者组成。Tβ4和CD4水平也通过商用ELISA试剂盒进行测定。结果显示，第2组血清Tβ4和CD4水平分别比第1组显著降低，P值分别<0.003和<0.019。Tβ4和CD4与维生素A水平均呈正相关，P值分别<0.000和<0.003，且彼此之间的P值<0.000。我们得出结论，维生素A缺乏可能会影响Tβ4和CD4的水平。