[生物反应调节剂对放射治疗效果的改善作用]
[Improvement in the effects of radiation therapy with BRM].
作者信息
Inomata T, Ogawa Y, Nishioka A, Maeda T, Seguchi H
机构信息
Dept. of Radiology, Kochi Med. School.
出版信息
Gan No Rinsho. 1990 Oct;36(13):2278-85.
The effects of radiation therapy and Sonifilan (SPG; a glucan produced by Schizophyllum commune) on the control of the primary lesion of human uterine cervix cancer and the experimental metastasis with mice were studied. SPG had excellent effects on the uterine cervix cancer compared with radiation therapy alone. Furthermore, immunohistochemical study showed that tumor infiltrated monocytes in good responders were mainly occupied with helper/induced T lymphocytes. SPG also suppressed the experimental lung metastasis especially with radiation therapy. Metastatic tumor infiltrated monocytes were many macrophages, which was the same as in inoculated local tumor.
研究了放射治疗和裂褶菌多糖（SPG；一种由裂褶菌产生的葡聚糖）对人类子宫颈癌原发灶控制及小鼠实验性转移的影响。与单纯放射治疗相比，SPG对子宫颈癌有显著效果。此外，免疫组织化学研究表明，反应良好的肿瘤浸润单核细胞主要由辅助/诱导性T淋巴细胞占据。SPG还尤其在放射治疗时抑制了实验性肺转移。转移性肿瘤浸润单核细胞中有许多巨噬细胞，这与接种局部肿瘤中的情况相同。
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