School of Chemistry, The University of Sydney, NSW 2006, Australia.
Org Lett. 2011 Feb 18;13(4):680-3. doi: 10.1021/ol102916b. Epub 2011 Jan 14.
The total synthesis of the 43 amino acid antibacterial peptide Microcin B17 (MccB17) is described. The natural product was synthesized via a convergent approach from a heterocycle-derived peptide and peptide thioester fragments prepared via Fmoc-strategy solid phase peptide synthesis (SPPS). Final assembly was achieved in an efficient manner using two Ag(I)-assisted peptide ligation reactions to afford MccB17 in excellent overall yield.
本文描述了 43 个氨基酸抗菌肽 Microcin B17（MccB17）的全合成。该天然产物通过杂环衍生肽和通过 Fmoc 策略固相肽合成（SPPS）制备的肽硫酯片段的汇聚方法合成。最终组装通过两种 Ag（I）辅助的肽连接反应以优异的总收率有效地实现，从而得到 MccB17。
