内皮型一氧化氮合酶在脑血管调节中的作用。
Role of endothelial nitric oxide in cerebrovascular regulation.
机构信息
Cardiovascular Research Center and Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
出版信息
Curr Pharm Biotechnol. 2011 Sep;12(9):1334-42. doi: 10.2174/138920111798280974.
Abstract
Endothelial nitric oxide (NO) plays important roles in the vascular system. Animal models that show vascular dysfunction demonstrate the protective role of endothelial NO dependent pathways. This review focuses on the role of endothelial NO in the regulation of cerebral blood flow and vascular tone. We will discuss the importance of NO in cerebrovascular function using animal models with altered endothelial NO production under normal, ischemic and reperfusion conditions, as well as in hyperoxia. Pharmacological and genetic manipulations of the endothelial NO system demonstrate the essential roles of endothelial NO synthase in maintenance of vascular tone and cerebral perfusion under normal and pathological conditions.
摘要
内皮型一氧化氮（NO）在血管系统中发挥着重要作用。表现出血管功能障碍的动物模型表明，内皮型 NO 依赖途径具有保护作用。本综述重点讨论了内皮型 NO 在调节脑血流和血管张力中的作用。我们将使用在正常、缺血和再灌注条件下以及高氧环境下内皮型 NO 产生改变的动物模型，讨论 NO 在脑血管功能中的重要性。内皮型 NO 系统的药理学和遗传学操作表明，内皮型一氧化氮合酶在正常和病理条件下维持血管张力和脑灌注中起着重要作用。
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