Department of Internal Medicine, Division of Pulmonary and Critical Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA.
Trends Cardiovasc Med. 1998 Feb;8(2):51-8. doi: 10.1016/S1050-1738(97)00128-X.
Recent evidence demonstrates that members of the CXC chemokine family can act as either angiogenic or angiostatic factors, depending on the presence of the ELR (Glu-Leu-Arg) motif in their NH(2) terminus. As such, these molecules have been shown to regulate tumor growth and metastasis in an animal model of human non-small cell lung cancer. ELR-positive members (for example, IL-8) are tumor-derived proteins that promote tumor growth and metastasis. Conversely, ELR-negative members (for example, IP-10 and MIG) are endogenous factors that inhibit tumor growth and metastasis. The levels of these factors in human tumor specimens may have predictive value for determining which patients are at risk for developing metastasis, and alteration of these CXC chemokine levels may provide a therapeutic intervention.
最近的证据表明，CXC 趋化因子家族的成员可以根据其 NH（2）末端是否存在 ELR（Glu-Leu-Arg）基序，充当血管生成或血管抑制因子。因此，这些分子已被证明可以在人类非小细胞肺癌的动物模型中调节肿瘤生长和转移。ELR 阳性成员（例如，IL-8）是促进肿瘤生长和转移的肿瘤衍生蛋白。相反，ELR 阴性成员（例如，IP-10 和 MIG）是抑制肿瘤生长和转移的内源性因子。这些因子在人类肿瘤标本中的水平可能对确定哪些患者有发生转移的风险具有预测价值，并且改变这些 CXC 趋化因子水平可能提供治疗干预。
