Moore B B, Arenberg D A, Addison C L, Keane M P, Polverini P J, Strieter R M
Department of Internal Medicine, Division of Pulmonary and Critical Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0642, USA.
Angiogenesis. 1998;2(2):123-34. doi: 10.1023/a:1009284305061.
The CXC chemokines have recently been identified as a family of molecules which can regulate angiogenesis. Members of this family which contain the amino acid motif Glu-Leu-Arg in their amino terminus (ELR(+)) act as angiogenic factors, while ELR(-) members act as angiostatic molecules. The balance of these angiogenic versus angiostatic factors is critical in regulating homeostasis. As we detail in this review, there is increasing evidence from a variety of tumor model systems to suggest that the angiogenic members of this family and their receptors may be playing an important role in the neovascular pathology of solid tumors. In contrast, the angiostatic effects of the ELR- family members may provide novel therapeutic strategies for treating many tumors.
CXC趋化因子最近被确定为一类可调节血管生成的分子家族。该家族中在其氨基末端含有氨基酸基序Glu-Leu-Arg（ELR(+)）的成员充当血管生成因子，而ELR(-)成员则充当血管生成抑制分子。这些血管生成因子与血管生成抑制因子之间的平衡对于调节体内稳态至关重要。正如我们在本综述中详细阐述的那样，来自各种肿瘤模型系统的证据越来越多，表明该家族的血管生成成员及其受体可能在实体瘤的新生血管病理过程中发挥重要作用。相比之下，ELR-家族成员的血管生成抑制作用可能为治疗许多肿瘤提供新的治疗策略。
