Abdel Gadir A, Mowafi R S, Alnaser H M, Alrashid A H, Alonezi O M, Shaw R W
Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University Health Science Centre.
Clin Endocrinol (Oxf). 1990 Nov;33(5):585-92. doi: 10.1111/j.1365-2265.1990.tb03896.x.
Eighty-eight clomiphene citrate-resistant infertile patients with oligomenorrhoea or amenorrhoea attributable to polycystic ovarian disease were divided at random into three groups. Twenty-nine patients were treated with ovarian electrocautery, 30 with human menopausal gonadotrophins (hMG) and 29 with pure follicle stimulating hormone (FSH). Successful ovulation was induced in 71.4, 70.6 and 66.7% of the cycles in the groups respectively. Ten patients conceived after electrocautery and pure FSH therapy while 15 conceived after hMG medication (chi-squared = 1.6464, P = 0.439). The six-cycle cumulative pregnancy rate in the three consecutive groups was 52.1, 55.4, and 38.3%. Four further pregnancies were achieved after treating 10 patients in the electrocautery group with clomiphene citrate (100 mg/day for 5 days) for 25 cycles. The rate of pregnancy wastage in the corresponding groups was 21.4, 53.3 and 40% (chi-squared = 3.127, P = 0.2039). Ovarian electrocautery is equally effective as hMG and pure FSH in the treatment of PCO patients resistant to clomiphene citrate therapy.
88例因多囊卵巢疾病导致月经过少或闭经且对枸橼酸氯米芬耐药的不孕患者被随机分为三组。29例患者接受卵巢电灼治疗，30例接受人绝经期促性腺激素（hMG）治疗，29例接受纯卵泡刺激素（FSH）治疗。三组患者分别有71.4%、70.6%和66.7%的周期成功诱导排卵。电灼治疗组和纯FSH治疗组分别有10例患者受孕，hMG治疗组有15例患者受孕（卡方检验=1.6464，P=0.439）。三组连续六个周期的累积妊娠率分别为52.1%、55.4%和38.3%。电灼治疗组10例患者接受枸橼酸氯米芬（100mg/天，共5天）治疗25个周期后又有4例受孕。相应组的流产率分别为21.4%、53.3%和40%（卡方检验=3.127，P=0.2039）。在治疗对枸橼酸氯米芬治疗耐药的多囊卵巢患者方面，卵巢电灼治疗与hMG和纯FSH同样有效。
