Gadir A A, Alnaser H M, Mowafi R S, Shaw R W
Faculty of Medicine, Safat, Kuwait.
Fertil Steril. 1992 Feb;57(2):309-13. doi: 10.1016/s0015-0282(16)54836-5.
To compare the effect of ovarian electrocautery versus an intranasal (IN) luteinizing hormone-releasing hormone agonist (LH-RH-a) in the response of patients with polycystic ovarian disease (PCOD) to human menopausal gonadotropin (hMG) therapy.
A prospective study with serial randomization of patients in two groups for treatment with ovarian electrocautery + hMG or LH-RH-a + hMG.
A teaching hospital reproductive endocrinology clinic.
Thirty-three women with PCOD who failed to conceive after six treatment cycles with hMG.
Midcycle and luteal phase endocrinology, ovulation, pregnancy rates (PRs), and miscarriage rates.
There was no difference in the ovulation or PRs between the two groups. However, the number of cycles with multiple dominant follicles, the luteal phase serum testosterone, and the miscarriage rate were lower in the group pretreated with ovarian electrocautery.
Pretreatment of patients with PCOD with ovarian electrocautery may be a better alternative to IN LH-RH-a therapy for induction of ovulation with hMG.
比较多囊卵巢疾病（PCOD）患者在接受人绝经期促性腺激素（hMG）治疗时，卵巢电灼术与鼻内（IN）促黄体生成激素释放激素激动剂（LH-RH-a）的疗效。
一项前瞻性研究，将患者连续随机分为两组，分别接受卵巢电灼术+hMG或LH-RH-a+hMG治疗。
一家教学医院的生殖内分泌门诊。
33例PCOD患者，经hMG六个治疗周期后仍未受孕。
周期中期和黄体期内分泌指标、排卵情况、妊娠率（PRs）和流产率。
两组的排卵情况或妊娠率无差异。然而，卵巢电灼术预处理组多个优势卵泡的周期数、黄体期血清睾酮水平和流产率较低。
对于PCOD患者，在使用hMG诱导排卵时，卵巢电灼术预处理可能是比鼻内LH-RH-a治疗更好的选择。
