Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands.
Eur Neuropsychopharmacol. 2011 Jul;21(7):532-44. doi: 10.1016/j.euroneuro.2010.12.001. Epub 2011 Jan 14.
Current approaches to dissect the molecular neurobiology of complex neuropsychiatric disorders such as schizophrenia and major depression have been rightly criticized for failing to provide benefits to patients. Improving the translational potential of our efforts will require the development and refinement of better disease models that consider a wide variety of contributing factors, such as genetic variation, gene-by-environment interactions, endophenotype or intermediate phenotype assessment, cross species analysis, sex differences, and developmental stages. During a targeted expert meeting of the European College of Neuropsychopharmacology (ECNP) in Istanbul, we addressed the opportunities and pitfalls of current translational animal models of psychiatric disorders and agreed on a series of core guidelines and recommendations that we believe will help guiding further research in this area.
目前，人们采用多种方法来剖析精神分裂症和重度抑郁症等复杂神经精神疾病的分子神经生物学，但这些方法并没有给患者带来明显的益处，因此受到了广泛的批评。为了提高我们研究的转化潜力，需要开发和完善更好的疾病模型，这些模型应考虑到多种致病因素，如遗传变异、基因-环境相互作用、表现型或中间表型评估、跨物种分析、性别差异和发育阶段等。在伊斯坦布尔举行的欧洲神经精神药理学学院（ECNP）专题专家会议上，我们讨论了当前精神疾病转化动物模型的机遇和挑战，并就一系列核心指导原则和建议达成了一致，我们认为这些原则和建议将有助于指导该领域的进一步研究。
