Kalueff Allan V, Ren-Patterson Renee F, LaPorte Justin L, Murphy Dennis L
Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892-1264, USA.
Behav Brain Res. 2008 Apr 9;188(2):243-9. doi: 10.1016/j.bbr.2007.11.011. Epub 2007 Nov 22.
Genetic and environmental factors play a key role in psychiatric disorders. While some disorders display exceptionally high heritability, others show gene x experience x personality interactions, contributing complexity to psychiatric phenotypes. As some brain disorders frequently overlap and co-occur (representing a continuum or spectrum of phenomena), modern psychiatry is shifting from "artificial" heterogeneity to the recognition of common elements in the pathogenesis of emotional, personality and behavioral disorders. Genetic animal models of these disorders represent an important direction of research, and are widely used to explore the role of different genes in brain mechanisms. Several concepts (such as endophenotypes, gene x environment interactions, and cross-species trait genetics) have been suggested for animal experimentation in this field. Here we develop a new concept based on targeting the complex interplay between different behavioral domains, meant to foster high-throughput phenotyping and integrative modeling of psychiatric disorders.
遗传和环境因素在精神疾病中起着关键作用。虽然一些疾病表现出极高的遗传度，但其他疾病则显示出基因×经历×人格相互作用，这增加了精神疾病表型的复杂性。由于一些脑部疾病经常重叠和同时出现（代表一系列连续或谱状现象），现代精神病学正从“人为的”异质性转向认识情绪、人格和行为障碍发病机制中的共同要素。这些疾病的遗传动物模型是一个重要的研究方向，被广泛用于探索不同基因在脑机制中的作用。针对该领域的动物实验，已提出了几个概念（如内表型、基因×环境相互作用和跨物种性状遗传学）。在此，我们基于针对不同行为领域之间的复杂相互作用提出了一个新概念，旨在促进精神疾病的高通量表型分析和综合建模。
