Lin S Y, Cai H, Gong Q Y, Yang Z C, Zhou J H, Zhang D, Zhang Z K
Shanghai Medical University.
Chin Med J (Engl). 1990 Sep;103(9):748-53.
The plasma endothelin (ET) level in spontaneously hypertensive rats (SHR) and 2K1C hypertension animal models and its vasoconstrictive effect on renal and tail arteries were studied. The results demonstrated that there was no difference in plasma ET level between the hypertensive groups SHR, 2K1C, normotensive control groups Wistar Kyot (WKY) and Sprague Dawley (SD), while the vasoconstrictive effect of ET in SHR was more dominant than in WKY. The EC50 of the renal and tail arteries in SHR (0.8912 +/- 0.1662 x 10(-8) M, 0.6103 +/- 0.0878 x 10(-8) M) was apparently lower than that in WKY (1.77 +/- 0.2991 x 10(-8) M, 1.2267 +/- 0.2502 x 10(-8) M, P less than 0.05), but no difference was found in 2K1C and SD rats. The four groups of animals exhibited no difference of such effects as response to norepine-phrine (NA). The findings suggested that the increased arteriole sensitivity to ET be an important factor in the pathogenesis of hypertension in SHR.
研究了自发性高血压大鼠（SHR）和二肾一夹（2K1C）高血压动物模型的血浆内皮素（ET）水平及其对肾动脉和尾动脉的血管收缩作用。结果表明，高血压组SHR、2K1C与正常血压对照组京都Wistar大鼠（WKY）和斯普拉格-道利大鼠（SD）的血浆ET水平无差异，而ET对SHR的血管收缩作用比WKY更显著。SHR肾动脉和尾动脉的半数有效浓度（EC50）（0.8912±0.1662×10⁻⁸ M，0.6103±0.0878×10⁻⁸ M）明显低于WKY（1.77±0.2991×10⁻⁸ M，1.2267±0.2502×10⁻⁸ M，P<0.05），但2K1C大鼠和SD大鼠之间未发现差异。四组动物对去甲肾上腺素（NA）的反应等效应无差异。这些发现提示小动脉对ET敏感性增加是SHR高血压发病机制中的一个重要因素。
