Cai H
Zhonghua Yi Xue Za Zhi. 1990 Aug;70(8):446-9, 32.
The plasma endothelin (ET) level in SHR and 2K1C hypertension animal models and its vasoconstrictive effect in their renal and tail arteries were studied. The results demonstrated that there was no difference of plasma ET level between the hypertensive groups SHR, 2K1C and the normotensive control groups WKY and SD, while the vasoconstrictive effect of ET in SHR was were more predominant than that in WKY. The EC50 of the renal and tail arteries in SHR (0.8912 +/- 0.4398 x 10(-8) M, 0.6103 +/- 0.2633 x 10(-8) M) were apparently lower than those in WKY (1.711 +/- 0.7327 x 10(-8) M, 1.2667 +/- 0.6129 x 10(-8) M, (P less than 0.05); but there was no difference between 2K1C and SD rats. The four groups of animals mentioned above exhibited no differences of such effects in response to norepinephrine (NA). The results suggested that the increased arteriole sensitivity to ET was an important factor in the pathogenesis of hypertension in SHR.
研究了自发性高血压大鼠（SHR）和二肾一夹（2K1C）高血压动物模型的血浆内皮素（ET）水平及其对肾动脉和尾动脉的血管收缩作用。结果表明，高血压组SHR、2K1C与正常血压对照组WKY、SD之间的血浆ET水平无差异，而ET对SHR的血管收缩作用比WKY更显著。SHR肾动脉和尾动脉的半数有效浓度（EC50）（0.8912±0.4398×10⁻⁸ M，0.6103±0.2633×10⁻⁸ M）明显低于WKY（1.711±0.7327×10⁻⁸ M，1.2667±0.6129×10⁻⁸ M，P＜0.05）；但2K1C大鼠与SD大鼠之间无差异。上述四组动物对去甲肾上腺素（NA）的反应在这种作用方面无差异。结果提示，小动脉对ET敏感性增加是SHR高血压发病机制中的一个重要因素。
