整合素基因多态性与淋巴瘤风险。
Polymorphisms in integrin genes and lymphoma risk.
机构信息
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7240, USA.
出版信息
Leuk Res. 2011 Jul;35(7):968-70. doi: 10.1016/j.leukres.2010.12.012. Epub 2011 Jan 15.
Immune deficiency is one of the best characterized and strongest known risk factors for non-Hodgkin lymphoma (NHL). We studied the association between single nucleotide polymorphisms (SNPs) in integrin genes that are important components in human innate immunity and the risk of NHL in a population-based case-control study of women in Connecticut, USA. A total of 373 tag SNPs in 33 gene regions were included in the analysis of 448 cases and 525 controls. The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma. Two gene regions (ADAM19 (P=0.009) and ICAM3 (P=0.009)) displayed global associations with lymphoma risk at the P<0.01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations.
免疫缺陷是已知的非霍奇金淋巴瘤（NHL）最强的特征和风险因素之一。我们在美国康涅狄格州进行了一项基于人群的女性病例对照研究，研究了整合素基因中的单核苷酸多态性（SNP）与 NHL 风险之间的关系，这些基因是人类先天免疫的重要组成部分。在对 448 例病例和 525 例对照进行的分析中，共包括 33 个基因区域的 373 个标记 SNP。ADAM19 rs11466782 SNP 与淋巴瘤风险增加相关（OR，1.73；95%CI，1.28-2.35；Padditive=0.0004），ICAM3 rs2304240（OR，0.67；95%CI，0.52-0.86；Padditive=0.002）和 PTGDR rs708486 SNP（OR，0.75；95%CI，0.63-0.90；Padditive=0.002）与淋巴瘤风险降低相关。两个基因区域（ADAM19（P=0.009）和 ICAM3（P=0.009））在 P<0.01 水平上显示出与淋巴瘤风险的整体关联。虽然我们的结果表明整合素基因中的遗传多态性可能在女性淋巴瘤的发生中起作用，但在其他人群中得到复制之前，这些结果应被视为探索性的。
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