JAK/STAT 信号通路基因多态性与非霍奇金淋巴瘤风险。
Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.
机构信息
Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Leuk Res. 2013 Sep;37(9):1120-4. doi: 10.1016/j.leukres.2013.05.003. Epub 2013 Jun 12.
Abstract
Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.
摘要
Janus 激酶/信号转导和转录激活因子（JAK/STAT）信号通路基因功能障碍可导致免疫缺陷和各种造血系统疾病。我们在康涅狄格州妇女的基于人群的病例对照研究中，评估了 12 个 JAK/STAT 通路基因（JAK3、STAT1、STAT2、STAT3、STAT4、STAT5a、STAT5b、STAT6、SCOS1、SCOS2、SCOS3 和 SCOS4）中的遗传多态性（SNP）与 NHL 风险之间的关联。我们在调整了多次比较后，确定了 STAT3（rs12949918 和 rs6503695）和 STAT4（rs932169）中的三个 SNP 与 NHL 风险相关。我们的结果表明，JAK/STAT 通路基因中的遗传变异可能在淋巴瘤发生中起作用，值得进一步研究。
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