Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
Neuroscientist. 2010 Dec;16(6):650-61. doi: 10.1177/1073858410386357.
Dendritic spines are small actin-rich protrusions that form the postsynaptic part of most excitatory synapses. They play critical roles in synaptic function and exhibit a striking degree of structural plasticity, which is closely linked to changes in strength of synaptic connections. Here the authors summarize recent work that has revealed an important relationship between the microtubule and actin cytoskeleton in controlling spine morphology and plasticity. Dynamic microtubules and the proteins that specifically associate with the growing microtubule plus-ends recently emerged as temporal and spatial regulators of actin organization, which controls dynamic changes in structure and function of dendritic spines.
树突棘是富含肌动蛋白的小突起，形成大多数兴奋性突触的突触后部分。它们在突触功能中起着关键作用，并表现出显著的结构可塑性，这与突触连接强度的变化密切相关。在这里，作者总结了最近的工作，这些工作揭示了微管和肌动蛋白细胞骨架在控制脊柱形态和可塑性方面的重要关系。动态微管和与生长中的微管正端特异性结合的蛋白质最近成为肌动蛋白组织的时空调节剂，控制树突棘结构和功能的动态变化。
