Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kusunoki-cho, 650-0017, Kobe, Japan.
J Rheumatol. 2011 Apr;38(4):680-4. doi: 10.3899/jrheum.100780. Epub 2011 Jan 15.
To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD).
Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined.
PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud's phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months.
PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP.
阐明血小板衍生的微颗粒（PDMP）在系统性红斑狼疮（SLE）、系统性硬皮病（SSc）、皮肌炎/多发性肌炎（PM/DM）和混合性结缔组织病（MCTD）中的作用。
通过 ELISA 测量 PDMP 水平，并在 4 种疾病中的患者之间进行比较。还检查了 PDMP 水平与患者临床特征和药物治疗的相关性。
MCTD 和 SSc 患者的 PDMP 水平高于对照组。多元线性回归分析显示，有雷诺现象（RP）的患者 PDMP 水平高于无 RP 的患者。个别患者的 PDMP 水平在几个月内没有明显波动。
PDMP 水平与 MCTD、SSc 和 RP 相关，可能是 RP 的一个新标志物。
