Department of Hematopathology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Pathology. 2011 Jan;43(1):54-7. doi: 10.1097/PAT.0b013e328340bbba.
Lymphomas of the penis are rare and can either arise at this site or be a manifestation of systemic disease. We report the case of an elderly man with a plasmablastic lymphoma (PBL) involving the uncircumcised penile prepuce. The neoplasm was composed of plasmablasts positive for monotypic immunoglobulin lambda light chain, CD3, CD79a, CD138 and Epstein-Barr virus encoded RNA (EBER), and was negative for CD2, CD5, CD7, CD20, and PAX5. This case is highly unusual for at least two reasons. The penile foreskin is a rare location for lymphoma and PBL at this site has not been reported. Secondly, the tumour was shown by immunohistochemistry to be positive for the T-cell marker CD3. Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed.
阴茎淋巴瘤较为罕见，可原发于该部位，也可表现为系统性疾病的一种。我们报告了一例老年男性的浆母细胞淋巴瘤（PBL）累及未行包皮环切术的阴茎包皮。肿瘤由浆母细胞组成，这些细胞单型免疫球蛋白 λ 轻链、CD3、CD79a、CD138 和 Epstein-Barr 病毒编码 RNA（EBER）阳性，而 CD2、CD5、CD7、CD20 和 PAX5 阴性。该病例至少有两个不寻常之处。阴茎包皮是淋巴瘤的罕见部位，而该部位的 PBL 尚未有报道。其次，免疫组化显示肿瘤 T 细胞标志物 CD3 阳性。终末分化 B 细胞淋巴瘤的谱系模糊性与免疫缺陷密切相关，并与 Epstein-Barr 病毒感染相关。还对阴茎淋巴瘤的文献进行了复习。
