肿瘤代谢物抑制 T 细胞应答。
Suppression of T-cell responses by tumor metabolites.
机构信息
Department of Internal Medicine 5, Hematology/Oncology, University of Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany.
出版信息
Cancer Immunol Immunother. 2011 Mar;60(3):425-31. doi: 10.1007/s00262-010-0967-1. Epub 2011 Jan 15.
Abstract
Tumor cells have developed multiple mechanisms to escape T-cell-mediated immune recognition. Recent work has revealed that the altered tumor metabolism depletes essential nutrients or leads to the accumulation of immunosuppressive metabolites in the tumor microenvironment. In this review, we discuss the suppressive activity of some metabolic key players, which are upregulated in human tumor cells, including indolamine-2,3-dioxygenase (IDO), arginase, inducible nitric oxide synthetase (iNOS), and lactate dehydrogenase (LDH)-A, on the adaptive immune system. A better understanding of the impact of metabolic alterations of tumor cells on effector T-cell functions could lead to new therapeutic strategies to improve the efficacy of cancer immunotherapy.
摘要
肿瘤细胞已经发展出多种机制来逃避 T 细胞介导的免疫识别。最近的研究揭示，改变的肿瘤代谢会耗尽必需的营养物质，或导致免疫抑制代谢物在肿瘤微环境中积累。在这篇综述中，我们讨论了一些代谢关键因子的抑制活性，这些因子在人类肿瘤细胞中上调，包括吲哚胺-2,3-双加氧酶（IDO）、精氨酸酶、诱导型一氧化氮合酶（iNOS）和乳酸脱氢酶（LDH）-A，它们对适应性免疫系统的影响。更好地了解肿瘤细胞代谢改变对效应 T 细胞功能的影响可能会导致新的治疗策略，以提高癌症免疫治疗的疗效。
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