Beth Israel Deaconess Medical Center, Joslin-Beth Israel Deaconess Foot Center and Microcirculation Lab, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Expert Opin Pharmacother. 2011 Mar;12(4):593-606. doi: 10.1517/14656566.2011.530658. Epub 2011 Jan 18.
Diabetic foot ulceration is a serious secondary complication of diabetes mellitus and the most common cause of hospitalization in diabetic patients. The etiology of diabetic foot ulcerations is complex due to their multifactorial nature. Thus, addressing all of the factors involved remains instrumental in wound healing.
The first part of this review focuses on the pathophysiology of diabetic foot ulceration and wound-healing impairment. The second part reviews the standard treatments, including advanced wound-care products and new therapeutic approaches currently under investigation. The reader will understand the most up-to-date research regarding the unique pathophysiology of diabetic foot ulceration along with the basic cornerstones of current recommended standard therapy.
Diabetic foot ulceration is a serious complication that can lead--potentially--to devastating lower-extremity amputations. Proper adherence to standard treatment strategies can potentially prevent the need for amputation.
糖尿病足溃疡是糖尿病的一种严重的继发性并发症，也是糖尿病患者住院的最常见原因。由于其多因素的性质，糖尿病足溃疡的病因较为复杂。因此，解决所有涉及的因素对于伤口愈合仍然是至关重要的。
这篇综述的第一部分侧重于糖尿病足溃疡和伤口愈合障碍的病理生理学。第二部分回顾了标准治疗方法，包括先进的伤口护理产品和目前正在研究的新治疗方法。读者将了解到有关糖尿病足溃疡独特病理生理学的最新研究，以及当前推荐的标准治疗的基本基石。
糖尿病足溃疡是一种严重的并发症，可能会导致下肢截肢——如果不及时治疗的话。适当遵循标准治疗策略可能可以预防需要截肢的情况。
