Theocharidis Georgios, Yuk Hyunwoo, Roh Heejung, Wang Liu, Mezghani Ikram, Wu Jingjing, Kafanas Antonios, Contreras Mauricio, Sumpio Brandon, Li Zhuqing, Wang Enya, Chen Lihong, Guo Chuan Fei, Jayaswal Navin, Katopodi Xanthi-Leda, Kalavros Nikolaos, Nabzdyk Christoph S, Vlachos Ioannis S, Veves Aristidis, Zhao Xuanhe
Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nat Biomed Eng. 2022 Oct;6(10):1118-1133. doi: 10.1038/s41551-022-00905-2. Epub 2022 Jul 4.
Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with bioengineered skin or with growth factors. However, most patients do not benefit from these treatments. Here we report the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adheres to diabetic wounds, and promotes wound closure and re-epithelialization. The patch consists of a dried adhesive layer of crosslinked polymer networks bound to a pre-stretched hydrophilic elastomer backing, and implements a hydration-based shape-memory mechanism to mechanically contract diabetic wounds in a programmable manner on the basis of analytical and finite-element modelling. In mouse and human skin, and in mini-pigs and humanized mice, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and the enrichment of fibroblast populations with a pro-regenerative phenotype. Strain-programmed patches might also be effective for the treatment of other forms of acute and chronic wounds.
糖尿病足溃疡和其他愈合受损的慢性伤口可用生物工程皮肤或生长因子进行治疗。然而，大多数患者并未从这些治疗中获益。在此，我们报告了一种应变编程贴片的研发及其临床前治疗性能，该贴片能快速且牢固地粘附于糖尿病伤口，促进伤口闭合和重新上皮化。该贴片由交联聚合物网络的干燥粘合剂层与预拉伸的亲水性弹性体背衬结合而成，并基于分析和有限元建模实现了一种基于水合作用的形状记忆机制，以可编程方式机械收缩糖尿病伤口。在小鼠和人类皮肤以及小型猪和人源化小鼠中，该贴片通过促进更快的重新上皮化和血管生成以及富集具有促再生表型的成纤维细胞群体，增强了糖尿病伤口的愈合。应变编程贴片可能对治疗其他形式的急性和慢性伤口也有效。
