Department of General Surgery, Landspitali University Hospital, Reykjavik, Iceland.
Acta Obstet Gynecol Scand. 2011 Feb;90(2):158-66. doi: 10.1111/j.1600-0412.2010.01035.x. Epub 2010 Dec 2.
Currently, it is estimated that approximately one in every 3,000 births are from women who have or are being treated for breast cancer. Although rare, the incidence of pregnancy-associated breast cancer (PABC) is increasing as women are delaying childbirth. Diagnostic and treatment recommendations have been mainly based on evidence from retrospective single institutional and collective series and expert consensus, as randomized trials on this entity are understandably lacking. PABC is often associated with a poor outcome, but this is mainly due to delay in diagnosis and initiation of treatment. For the most part, women with PABC should be managed like non-pregnant breast cancer patients and should expect a similar outcome, without causing harm to the unborn child. Increased awareness and knowledge of how to assess symptomatic breast problems in pregnancy and a specialized multidisciplinary team approach for established PABC is likely to improve outcomes. This review analyses the evidence on the diagnosis, treatment and prognosis of patients with PABC.
目前，据估计，每 3000 名分娩的妇女中就有 1 名患有或正在接受乳腺癌治疗。尽管罕见，但随着女性生育年龄的推迟，妊娠相关性乳腺癌（PABC）的发病率正在上升。诊断和治疗建议主要基于来自回顾性单机构和集体系列以及专家共识的证据，因为对该实体进行的随机试验是可以理解的。PABC 通常与不良预后相关，但这主要是由于诊断和治疗的延迟。在大多数情况下，患有 PABC 的女性应像非妊娠乳腺癌患者一样进行管理，并期望获得类似的结果，而不会对未出生的孩子造成伤害。提高对如何评估妊娠中症状性乳腺问题的认识和知识，以及为确诊的 PABC 提供专门的多学科团队方法，可能会改善预后。这篇综述分析了 PABC 患者的诊断、治疗和预后的证据。
