Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Department of Obstetrics and Gynecology, Division of Perinatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Breast Care (Basel). 2014 Oct;9(5):355-9. doi: 10.1159/000366436.
The primary objective of this study was to evaluate the clinicopathological characteristics of patients with pregnancy-associated breast cancer (PABC), with a special focus on diagnostic delays and the identifiable causes of diagnostic delays.
Clinicopathological data of patients treated for PABC between 2003 and 2012 at Hacettepe University Hospital was retrospectively reviewed.
20 patients with PABC were included. The pathological examination revealed predominance of invasive ductal carcinoma (80%), grade III tumors (65%) and advanced-stage (III-IV) disease (75%). In 8 patients (40%), there was a diagnostic delay between occurrence of the presenting symptoms and the initiation of breast mass workup. For these 8 patients, the main identifiable causes of diagnostic delay were the attribution of disease-related symptoms to pregnancy or lactation in 5 (63%) and negligence of symptoms in 2 (25%).
PABC mostly presents with advanced-stage disease, and there can be a substantial diagnostic delay before these patients receive treatment. Preconceptional, gestational and postpartum examination of women of reproductive age should include a thorough breast examination and should provide adequate information regarding the physiological changes in breast tissue and the possible pathological symptoms.
本研究的主要目的是评估妊娠相关性乳腺癌（PABC）患者的临床病理特征，特别关注诊断延迟及其可识别的原因。
回顾性分析 2003 年至 2012 年在哈塞特佩大学医院治疗的 PABC 患者的临床病理资料。
共纳入 20 例 PABC 患者。病理检查显示浸润性导管癌（80%）、III 级肿瘤（65%）和晚期（III-IV 期）疾病（75%）为主。在 8 例（40%）患者中，存在从出现症状到开始进行乳腺肿块检查之间的诊断延迟。对于这 8 例患者，诊断延迟的主要可识别原因是将疾病相关症状归因于妊娠或哺乳期 5 例（63%）和忽视症状 2 例（25%）。
PABC 主要表现为晚期疾病，这些患者在接受治疗前可能存在较大的诊断延迟。在有生育能力的妇女进行孕前、妊娠期和产后检查时，应包括彻底的乳房检查，并提供有关乳房组织生理变化和可能的病理症状的充分信息。
