INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Hôpital Tenon, F-75020, Paris, France.
Acta Paediatr. 2011 Mar;100(3):370-8. doi: 10.1111/j.1651-2227.2010.02064.x. Epub 2011 Jan 17.
To assess cerebral lesions and other medical as well as social characteristics as predictors of risk of mild and severe cognitive deficiencies in very preterm infants.
As part of the EPIPAGE population-based prospective cohort study, perinatal data and cognitive outcome at 5 years of age were recorded for 1503 infants born before 33 weeks of gestation in nine regions of France in 1997. Mild cognitive deficiency was defined as a Mental Processing Composite score on the Kaufman Assessment Battery for Children test of between 70 and 84, and severe cognitive deficiency as a score of <70.
After controlling for cerebral lesions and other medical as well as social factors, low parental socio-economic status and lack of breastfeeding were significant predictors of mild and severe cognitive deficiencies, whereas presence of cerebral lesions, being small for gestational age and having a large number of siblings were predictors of severe cognitive deficiency.
Predictors of poor cognitive outcome in very preterm infants are low social status, lack of breastfeeding, presence of cerebral lesions on ultrasound scan, being born small for gestational age and having a high number of siblings. Social factors predicted both mild and severe cognitive deficiencies, whereas medical factors predicted mostly severe cognitive deficiencies.
评估脑损伤以及其他医学和社会特征，以预测极早产儿轻度和重度认知缺陷的风险。
作为 EPIPAGE 基于人群的前瞻性队列研究的一部分，记录了 1997 年法国 9 个地区 1503 名胎龄<33 周早产儿的围产期数据和 5 岁时的认知结果。轻度认知缺陷定义为 Kaufman 儿童评估成套测验中的心理处理综合得分在 70-84 之间，重度认知缺陷定义为得分<70。
在控制了脑损伤以及其他医学和社会因素后，低父母社会经济地位和缺乏母乳喂养是轻度和重度认知缺陷的显著预测因素，而脑损伤、小于胎龄以及有较多兄弟姐妹是重度认知缺陷的预测因素。
极早产儿认知结局不良的预测因素是社会地位低、缺乏母乳喂养、超声扫描存在脑损伤、小于胎龄出生和有较多兄弟姐妹。社会因素预测了轻度和重度认知缺陷，而医学因素主要预测了重度认知缺陷。
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