Department of Nephrology, Dialysis and Transplantation, University of Modena and Reggio Emilia Medical School, Modena, Italy.
J Exp Clin Cancer Res. 2011 Jan 17;30(1):9. doi: 10.1186/1756-9966-30-9.
Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim is to take a correct view of the available stem cell subtypes and their rational use in the medical area, with a specific focus on their therapeutic benefits and side effects. We have reviewed the main clinical trials dividing them basing on their clinical applications, and taking into account the ethical issue associated with the stem cell therapy.
We have searched Pubmed/Medline for clinical trials, involving the use of human stem cells, using the key words "stem cells" combined with the key words "transplantation", "pathology", "guidelines", "properties" and "risks". All the relevant clinical trials have been included. The results have been divided into different categories, basing on the way stem cells have been employed in different pathological conditions.
干细胞是关于细胞分化、分子过程和组织内稳态的重要信息来源，但也是治疗退行性疾病最有希望的生物工具之一。本综述重点介绍了人类干细胞的临床和实验应用。我们的目的是正确看待现有的干细胞亚型及其在医学领域的合理应用，特别关注它们的治疗益处和副作用。我们根据临床试验的临床应用，考虑与干细胞治疗相关的伦理问题，对主要的临床试验进行了回顾。
我们在 Pubmed/Medline 上搜索了涉及使用人类干细胞的临床试验，使用的关键词是“干细胞”，结合“移植”、“病理学”、“指南”、“特性”和“风险”。所有相关的临床试验都被包括在内。结果根据干细胞在不同病理条件下的应用方式分为不同的类别。
