• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Stem cells: roadmap to the clinic.干细胞:通往临床的路线图。
J Clin Invest. 2010 Jan;120(1):8-10. doi: 10.1172/JCI41801.
2
A dive into the stem cells world.深入干细胞世界。
Panminerva Med. 2009 Mar;51(1):1-3.
3
Sources of stem cells for regenerative medicine.用于再生医学的干细胞来源。
Stem Cell Rev. 2008 Spring;4(1):3-11. doi: 10.1007/s12015-008-9010-8.
4
Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine.化学调控干细胞治疗和再生医学中的细胞命运
Cell Chem Biol. 2016 Aug 18;23(8):893-916. doi: 10.1016/j.chembiol.2016.07.007. Epub 2016 Aug 11.
5
Stem cells and regenerative medicine - future perspectives.干细胞与再生医学——未来展望。
Can J Physiol Pharmacol. 2012 Mar;90(3):327-35. doi: 10.1139/y2012-007. Epub 2012 Mar 8.
6
The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine.细胞多能性的“甜蜜”点:人类多能干细胞中的蛋白质糖基化及其在再生医学中的应用
Expert Opin Biol Ther. 2015 May;15(5):679-87. doi: 10.1517/14712598.2015.1021329. Epub 2015 Mar 3.
7
Regenerative medicine: a primer for paediatricians.再生医学:儿科医生入门指南。
Early Hum Dev. 2009 Nov;85(11):685-9. doi: 10.1016/j.earlhumdev.2009.08.059. Epub 2009 Sep 27.
8
Regenerative medicine: a 2009 overview.再生医学:2009年综述
J Intern Med. 2009 Oct;266(4):303-10. doi: 10.1111/j.1365-2796.2009.02157.x.
9
Pluripotent stem cells: the last 10 years.多能干细胞:过去十年
Regen Med. 2016 Dec;11(8):831-847. doi: 10.2217/rme-2016-0117. Epub 2016 Dec 2.
10
Differentiation of pluripotent stem cells for regenerative medicine.用于再生医学的多能干细胞分化
Biochem Biophys Res Commun. 2016 Feb 26;471(1):1-4. doi: 10.1016/j.bbrc.2016.01.182. Epub 2016 Feb 3.

引用本文的文献

1
Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases.利用再生医学中的干细胞生态位:治疗神经退行性疾病的创新途径。
Int J Mol Sci. 2024 Jan 12;25(2):993. doi: 10.3390/ijms25020993.
2
Promising Stem Cell therapy in the Management of HIV and AIDS: A Narrative Review.干细胞疗法在治疗HIV和艾滋病方面的前景:一篇叙述性综述
Biologics. 2022 Jul 8;16:89-105. doi: 10.2147/BTT.S368152. eCollection 2022.
3
Changes in the Expression of Pluripotency Factor Oct-4 and Intensity of Apoptosis in the Uterus during Spontaneous and Immune-Dependent Abortions in Mice.在自发性和免疫依赖性流产小鼠子宫中,多能性因子 Oct-4 的表达变化和细胞凋亡强度。
Bull Exp Biol Med. 2022 Apr;172(6):765-769. doi: 10.1007/s10517-022-05474-7. Epub 2022 May 2.
4
Bidirectional Regulation of Mouse Embryonic Stem Cell Proliferation by Nicotine Is Mediated Through Wnt Signaling Pathway.尼古丁对小鼠胚胎干细胞增殖的双向调节通过Wnt信号通路介导。
Dose Response. 2017 Nov 19;15(4):1559325817739760. doi: 10.1177/1559325817739760. eCollection 2017 Oct-Dec.
5
Role of Stro1+/CD44+ stem cells in myometrial physiology and uterine remodeling during pregnancy.Stro1+/CD44+干细胞在孕期子宫肌层生理及子宫重塑中的作用
Biol Reprod. 2017 Jan 1;96(1):70-80. doi: 10.1095/biolreprod.116.143461.
6
Generation of a Stable Transgenic Swine Model Expressing a Porcine Histone 2B-eGFP Fusion Protein for Cell Tracking and Chromosome Dynamics Studies.用于细胞追踪和染色体动力学研究的表达猪组蛋白2B-eGFP融合蛋白的稳定转基因猪模型的构建
PLoS One. 2017 Jan 12;12(1):e0169242. doi: 10.1371/journal.pone.0169242. eCollection 2017.
7
Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts.细胞过度增殖对人成纤维细胞的重编程效率产生负面影响。
Stem Cells Transl Med. 2015 Oct;4(10):1101-8. doi: 10.5966/sctm.2014-0217. Epub 2015 Aug 7.
8
CD34 and CD49f Double-Positive and Lineage Marker-Negative Cells Isolated from Human Myometrium Exhibit Stem Cell-Like Properties Involved in Pregnancy-Induced Uterine Remodeling.从人子宫肌层分离出的CD34和CD49f双阳性且谱系标志物阴性的细胞具有参与妊娠诱导的子宫重塑的干细胞样特性。
Biol Reprod. 2015 Aug;93(2):37. doi: 10.1095/biolreprod.114.127126. Epub 2015 Jun 24.
9
Hormonal regulation of hematopoietic stem cells and their niche: a focus on estrogen.造血干细胞及其微环境的激素调节:聚焦雌激素
Int J Stem Cells. 2015 May;8(1):18-23. doi: 10.15283/ijsc.2015.8.1.18.
10
Stro-1/CD44 as putative human myometrial and fibroid stem cell markers.Stro-1/CD44作为假定的人子宫肌层和平滑肌瘤干细胞标志物。
Fertil Steril. 2015 Jul;104(1):225-34.e3. doi: 10.1016/j.fertnstert.2015.04.021. Epub 2015 May 16.

本文引用的文献

1
The bioethics of stem cell research and therapy.干细胞研究与治疗的生命伦理学
J Clin Invest. 2010 Jan;120(1):71-5. doi: 10.1172/JCI40435.
2
Enabling stem cell therapies through synthetic stem cell-niche engineering.通过合成干细胞生态位工程实现干细胞疗法。
J Clin Invest. 2010 Jan;120(1):60-70. doi: 10.1172/JCI41158.
3
Progress toward the clinical application of patient-specific pluripotent stem cells.患者特异性多能干细胞临床应用的进展。
J Clin Invest. 2010 Jan;120(1):51-9. doi: 10.1172/JCI40553.
4
The therapeutic promise of the cancer stem cell concept.癌症干细胞概念的治疗前景。
J Clin Invest. 2010 Jan;120(1):41-50. doi: 10.1172/JCI41004.
5
Stem cells in human neurodegenerative disorders--time for clinical translation?人类神经退行性疾病中的干细胞——临床转化的时机?
J Clin Invest. 2010 Jan;120(1):29-40. doi: 10.1172/JCI40543.
6
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration.再生医学:心血管再生生物学中的发育范式。
J Clin Invest. 2010 Jan;120(1):20-8. doi: 10.1172/JCI40820.
7
Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.修复骨骼肌:骨骼肌干细胞的再生潜力。
J Clin Invest. 2010 Jan;120(1):11-9. doi: 10.1172/JCI40373.
8
Regulation and function of skeletal muscle stem cells.骨骼肌干细胞的调控与功能
Cold Spring Harb Symp Quant Biol. 2008;73:317-22. doi: 10.1101/sqb.2008.73.054. Epub 2009 Feb 9.
9
Generation and regeneration of cells of the liver and pancreas.肝脏和胰腺细胞的生成与再生。
Science. 2008 Dec 5;322(5907):1490-4. doi: 10.1126/science.1161431.
10
New ISSCR guidelines underscore major principles for responsible translational stem cell research.国际干细胞研究学会(ISSCR)的新指南强调了负责任的转化干细胞研究的主要原则。
Cell Stem Cell. 2008 Dec 4;3(6):607-9. doi: 10.1016/j.stem.2008.11.009.

干细胞:通往临床的路线图。

Stem cells: roadmap to the clinic.

机构信息

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston, Massachusetts, USA.

出版信息

J Clin Invest. 2010 Jan;120(1):8-10. doi: 10.1172/JCI41801.

DOI:10.1172/JCI41801
PMID:20051631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2798707/
Abstract

Over the last decade, a remarkable number of papers have been published in which the biology of stem cells is introduced with words and phrases such as "promise," "rapid progress," and "future therapies." To separate myth and hype from reality, the articles in this Stem Cells Review series comprise a rich resource on the state of this fast-paced field and provide a balanced perspective on some of the major advances. They recount what the field has achieved over the past decade and where the field is headed. They also highlight the challenges to be faced in translating what is indeed highly promising science into proven therapies that will regenerate and repair diseased tissues.

摘要

在过去的十年中,发表了大量的论文,其中引入了“承诺”、“快速进展”和“未来疗法”等词语来介绍干细胞生物学。为了将神话和炒作与现实区分开来,本干细胞评论系列中的文章构成了一个关于这个快速发展领域的丰富资源,并提供了对一些主要进展的平衡观点。它们讲述了该领域在过去十年中所取得的成就,以及该领域的发展方向。它们还强调了将确实非常有前途的科学转化为能够再生和修复患病组织的经过验证的疗法所面临的挑战。