Jeffery S, Wilson C A, Carter N D
Department of Child Health, St. George's Hospital Medical School, London, United Kingdom.
Horm Metab Res. 1990 Sep;22(9):467-9. doi: 10.1055/s-2007-1004949.
Thyroidectomy has a feminizing effect on the carbonic anhydrase isozymes II and III in male rat liver. These isozymes are known to be sexually differentiated but no treatment so far administered has produced total feminization and this is also true for thyroidectomy. Neonatal castration, however, does produce this result, suggesting the possibility of androgen imprinting for these isozymes during the neonatal period.
甲状腺切除术对雄性大鼠肝脏中的碳酸酐酶同工酶II和III具有雌性化作用。已知这些同工酶存在性别差异，但迄今为止所采用的任何治疗方法都未实现完全雌性化，甲状腺切除术也是如此。然而，新生期阉割确实会产生这一结果，这表明在新生期这些同工酶可能存在雄激素印记。
