Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Hypertension. 2011 Mar;57(3):421-7. doi: 10.1161/HYPERTENSIONAHA.110.164517. Epub 2011 Jan 17.
Increased arterial stiffness is associated with higher levels of aortic wave reflection and aortic blood pressure. Recent evidence suggests a link between muscle sympathetic nerve activity and indices of arterial stiffness. Therefore, the aims of this study were to examine the relationship between resting muscle sympathetic nerve activity and characteristics of aortic pressure wave reflection and the influence of sex on these relationships. In 44 subjects (23 females and 21 males; 25 ± 1 years of age), we measured muscle sympathetic nerve activity via peroneal microneurography. In addition, noninvasive aortic pressure waveforms were synthesized from radial pressure waveforms obtained from applanation tonometry. Aortic blood pressure, augmentation index, wave reflection amplitude, and wasted left ventricular energy were calculated. Resting sympathetic activity (bursts/100 heart beats) was not associated with any of the aortic pressure wave reflection characteristics for all patients. However, there was a positive relationship between sympathetic activity and augmentation index (r = 0.46; P = 0.05) in men. Further, sympathetic activity in men was related to wave reflection amplitude (r = 0.53; P<0.05) and wasted left ventricular energy (r = 0.57; P<0.01). In contrast to men, women demonstrated strong inverse relationships between sympathetic activity and augmentation index (r = -0.63), wave reflection amplitude ( r = -0.59), and wasted left ventricular energy (r = -0.58; P<0.01 for all). Our results suggest another possible mechanism by which young women are protected against the development of cardiovascular disease.
动脉僵硬度增加与主动脉波反射和主动脉血压水平升高有关。最近的证据表明，肌肉交感神经活动与动脉僵硬度指数之间存在联系。因此，本研究的目的是检查静息肌肉交感神经活动与主动脉压力波反射特征之间的关系，以及性别对这些关系的影响。在 44 名受试者（23 名女性和 21 名男性；25±1 岁）中，我们通过腓肠神经微神经图测量了肌肉交感神经活动。此外，从应用测压法获得的桡动脉压力波形合成了无创性主动脉压力波形。计算了主动脉血压、增强指数、波反射幅度和左心室能量浪费。静息交感神经活动（每 100 次心跳的爆发次数）与所有患者的主动脉压力波反射特征均无相关性。然而，在男性中，交感神经活动与增强指数呈正相关（r=0.46；P=0.05）。此外，男性的交感神经活动与波反射幅度（r=0.53；P<0.05）和左心室能量浪费（r=0.57；P<0.01）相关。与男性相比，女性的交感神经活动与增强指数（r=-0.63）、波反射幅度（r=-0.59）和左心室能量浪费（r=-0.58；P<0.01）呈强烈的负相关。我们的结果表明，年轻女性免受心血管疾病发展影响的另一个可能机制。
