Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjyuku-ku, Tokyo 160-0023, Japan.
Br J Ophthalmol. 2011 Sep;95(9):1251-4. doi: 10.1136/bjo.2010.191288. Epub 2011 Jan 17.
To report the clinical features and causative virus of bilateral acute retinal necrosis (BARN) with a long interval after the initial onset.
The causative virus and clinical features were retrospectively investigated in four patients with delayed-onset BARN with an interval of more than 3 years after the onset of the disease in the initially affected eye.
The intervals between the initially affected eye and the latter affected eye of the four cases were 8 years 7 months, 19 years 3 months, 9 years 7 months and 3 years 6 months. The fourth patient developed a second recurrence in the latter affected eye 17 years 6 months after the initial inflammation in the fellow eye. In all four cases, the same virus species, either varicella-zoster virus or herpes simplex virus, was detected in both eyes by PCR or antibody detection. In all cases, the final best-corrected visual acuity of the latter affected eye (20/20, 18/20, 20/20 and 12/20, respectively) was better than that of the initially affected eye (20 cm hand motion, light perception-negative, light perception-negative and light perception-positive, respectively).
The present findings indicate that delayed-onset BARN in the fellow eye was caused by the same herpes virus species that induced the disease in the first affected eye.
报告间隔初始发病时间 3 年以上的双侧急性视网膜坏死（BARN）的临床特征和致病病毒。
回顾性研究了 4 例双眼发病间隔超过 3 年的迟发性 BARN 的致病病毒和临床特征。
4 例患者双眼的发病间隔分别为 8 年 7 个月、19 年 3 个月、9 年 7 个月和 3 年 6 个月。第 4 例患者在对侧眼初次炎症后 17 年 6 月，后者受累眼再次复发。所有 4 例患者均通过 PCR 或抗体检测在双眼中检测到相同的病毒种类，即水痘带状疱疹病毒或单纯疱疹病毒。所有患者的后者受累眼（分别为 20/20、18/20、20/20 和 12/20）的最终最佳矫正视力均优于前者受累眼（分别为 20cm 手动、光感阴性、光感阴性和光感阳性）。
本研究结果表明，对侧眼迟发性 BARN 是由引起第一只受累眼发病的同种疱疹病毒引起的。
