Department of Ophthalmology, University of Erlangen-Nuremberg, Erlangen 91054, Germany.
Br J Ophthalmol. 2011 Oct;95(10):1437-41. doi: 10.1136/bjo.2010.190074. Epub 2011 Jan 17.
To investigate the influence of atypical retardation pattern (ARP) on the distribution of peripapillary retinal nerve fibre layer (RNFL) thickness measured with scanning laser polarimetry in healthy individuals and to compare these results with RNFL thickness from spectral domain optical coherence tomography (OCT) in the same subjects.
120 healthy subjects were investigated in this study. All volunteers received detailed ophthalmological examination, GDx variable corneal compensation (VCC) and Spectralis-OCT. The subjects were divided into four subgroups according to their typical scan score (TSS): very typical with TSS=100, typical with 99 ≥ TSS ≥ 91, less typical with 90 ≥ TSS ≥ 81 and atypical with TSS ≤ 80. Deviations from very typical normal values were calculated for 32 sectors for each group.
There was a systematic variation of the RNFL thickness deviation around the optic nerve head in the atypical group for the GDxVCC results. The highest percentage deviation of about 96% appeared temporal with decreasing deviation towards the superior and inferior sectors, and nasal sectors exhibited a deviation of 30%. Percentage deviations from very typical RNFL values decreased with increasing TSS. No systematic variation could be found if the RNFL thickness deviation between different TSS-groups was compared with the OCT results.
The ARP has a major impact on the peripapillary RNFL distribution assessed by GDx VCC; thus, the TSS should be included in the standard printout.
探讨非典型延迟模式（ARP）对健康个体中扫描激光偏振光测量的视盘周围视网膜神经纤维层（RNFL）厚度分布的影响，并将这些结果与同一受试者的光谱域光学相干断层扫描（OCT）的 RNFL 厚度进行比较。
本研究调查了 120 名健康受试者。所有志愿者均接受详细的眼科检查、GDx 可变角膜补偿（VCC）和 Spectralis-OCT 检查。根据他们的典型扫描评分（TSS）将受试者分为四组：非常典型（TSS=100）、典型（99≥TSS≥91）、不太典型（90≥TSS≥81）和非典型（TSS≤80）。为每组的 32 个扇区计算偏离非常典型正常值的情况。
在 GDxVCC 结果中，非典型组视盘周围 RNFL 厚度的偏差呈现出系统的变化。约 96%的最高百分比偏差出现在颞侧，随着向上下象限的偏差逐渐减小，鼻侧的偏差为 30%。随着 TSS 的增加，从非常典型的 RNFL 值的百分比偏差减小。如果将不同 TSS 组之间的 RNFL 厚度偏差与 OCT 结果进行比较，则无法发现系统变化。
ARP 对视盘周围 RNFL 分布有很大影响，因此 TSS 应包含在标准打印输出中。
