Department of Ophthalmology, Edouard Herriot Hospital, Lyon 1 University, Lyon, France.
Am J Ophthalmol. 2010 Dec;150(6):825-33. doi: 10.1016/j.ajo.2010.06.011. Epub 2010 Sep 18.
To evaluate and compare the regional relationships between visual field sensitivity and retinal nerve fiber layer (RNFL) thickness as measured by spectral-domain optical coherence tomography (OCT) and scanning laser polarimetry.
Prospective cross-sectional study.
One hundred and twenty eyes of 120 patients (40 with healthy eyes, 40 with suspected glaucoma, and 40 with glaucoma) were tested on Cirrus-OCT, GDx VCC, and standard automated perimetry. Raw data on RNFL thickness were extracted for 256 peripapillary sectors of 1.40625 degrees each for the OCT measurement ellipse and 64 peripapillary sectors of 5.625 degrees each for the GDx VCC measurement ellipse. Correlations between peripapillary RNFL thickness in 6 sectors and visual field sensitivity in the 6 corresponding areas were evaluated using linear and logarithmic regression analysis. Receiver operating curve areas were calculated for each instrument.
With spectral-domain OCT, the correlations (r(2)) between RNFL thickness and visual field sensitivity ranged from 0.082 (nasal RNFL and corresponding visual field area, linear regression) to 0.726 (supratemporal RNFL and corresponding visual field area, logarithmic regression). By comparison, with GDx-VCC, the correlations ranged from 0.062 (temporal RNFL and corresponding visual field area, linear regression) to 0.362 (supratemporal RNFL and corresponding visual field area, logarithmic regression). In pairwise comparisons, these structure-function correlations were generally stronger with spectral-domain OCT than with GDx VCC and with logarithmic regression than with linear regression. The largest areas under the receiver operating curve were seen for OCT superior thickness (0.963 ± 0.022; P < .001) in eyes with glaucoma and for OCT average thickness (0.888 ± 0.072; P < .001) in eyes with suspected glaucoma.
The structure-function relationship was significantly stronger with spectral-domain OCT than with scanning laser polarimetry, and was better expressed logarithmically than linearly. Measurements with these 2 instruments should not be considered to be interchangeable.
评估并比较频域光相干断层扫描（OCT）和扫描激光偏振仪测量的视野敏感度与视网膜神经纤维层（RNFL）厚度之间的区域关系。
前瞻性横断面研究。
对 120 例患者的 120 只眼（健康眼 40 只，疑似青光眼 40 只，青光眼 40 只）进行 Cirrus-OCT、GDx VCC 和标准自动视野计检查。从 OCT 测量椭圆的 256 个周边神经纤维层厚度的 1.40625 度每个区域和 GDx VCC 测量椭圆的 64 个周边神经纤维层厚度的 5.625 度每个区域提取原始数据。使用线性和对数回归分析评估 6 个区域的周边 RNFL 厚度与相应 6 个区域视野敏感度之间的相关性。为每种仪器计算接收者操作特征曲线的面积。
用频域 OCT，RNFL 厚度与视野敏感度之间的相关性（r²）范围从 0.082（鼻侧 RNFL 和相应的视野区，线性回归）到 0.726（上颞侧 RNFL 和相应的视野区，对数回归）。相比之下，用 GDx-VCC，相关性范围从 0.062（颞侧 RNFL 和相应的视野区，线性回归）到 0.362（上颞侧 RNFL 和相应的视野区，对数回归）。在两两比较中，这些结构-功能相关性通常与频域 OCT 比与 GDx VCC 更强，与对数回归比与线性回归更强。在青光眼眼中，OCT 上厚度的最大接收者操作曲线面积为 0.963±0.022（P<.001），在疑似青光眼眼中，OCT 平均厚度的最大接收者操作曲线面积为 0.888±0.072（P<.001）。
频域 OCT 的结构-功能关系明显强于扫描激光偏振仪，对数表达优于线性表达。这两种仪器的测量值不应被视为可互换的。
