Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Menopause. 2011 Jun;18(6):670-4. doi: 10.1097/gme.0b013e3181fcd9d4.
The aim of this study was to assess the impact of menopause, age, and women's symptoms and characteristics on quality of midlife.
This was a cross-sectional study of 151 healthy women aged 45 to 55 years attending university-affiliated menopause clinics. To obtain the data, a questionnaire designed by the investigators and based on the Greene Climacteric Scale and the Utian Menopause-Specific Quality of Life scale was self-completed by the participants.
A significant gradual increase in the total Greene Climacteric Scale score was observed from premenopausal to perimenopausal and postmenopausal women (P = 0.02), specifically in the vasomotor and sexual subscores (P < 0.0001 and P = 0.001, respectively). In contrast, the total quality-of-life score remained stable in every specific aspect (occupation, health, emotion, and sex) throughout the menopausal transition (P = 0.8). A significant correlation was found between the psychological, somatic, and sexual Greene Climacteric Scale subscores and the Utian quality-of-life score (r = -0.46, P < 0.001; r = -0.29, P < 0.05; r = -0.28, P < 0.05, respectively), whereas the vasomotor subscore had no impact on midlife quality. The number of children was the only demographic factor that had a significant impact on the Utian score (P < 0.05) and to a higher extent than the climacteric syndrome. Hormone therapy equalizes the climacteric symptom profile of users to that of nonusers, yet both users and nonusers reported similar scores of midlife quality.
Menopause-specific quality of life may be affected by both demographic and climacteric parameters. Menopausal symptoms, but not vasomotor symptoms, have a negative impact on midlife quality, yet to a lesser degree than does the number of children.
本研究旨在评估绝经期、年龄以及女性症状和特征对中年生活质量的影响。
这是一项横断面研究，共纳入 151 名年龄在 45 至 55 岁之间、在大学附属绝经期诊所就诊的健康女性。为了获取数据，参与者自行填写了由研究者设计的、基于 Greene 绝经症状量表和 Utian 绝经特定生活质量量表的问卷。
从绝经前期到绝经前期和绝经后期女性，总 Greene 绝经症状量表评分显著逐渐增加（P = 0.02），特别是在血管舒缩和性亚量表方面（P < 0.0001 和 P = 0.001）。相比之下，在整个绝经期过渡期间，每个特定方面（职业、健康、情绪和性生活）的总生活质量评分均保持稳定（P = 0.8）。心理、躯体和性 Greene 绝经症状量表亚量表与 Utian 生活质量评分之间存在显著相关性（r = -0.46，P < 0.001；r = -0.29，P < 0.05；r = -0.28，P < 0.05），而血管舒缩症状亚量表对中年生活质量没有影响。孩子的数量是唯一对 Utian 评分有显著影响的人口统计学因素（P < 0.05），其影响程度高于绝经综合征。激素治疗使使用者和非使用者的绝经症状谱趋于一致，但两者的生活质量评分相似。
绝经特异性生活质量可能受人口统计学和绝经参数的影响。绝经症状，而非血管舒缩症状，对中年生活质量有负面影响，但影响程度小于孩子的数量。
