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颅内和椎管多发孤立性纤维瘤:病例报告。

Solitary fibrous tumor with multiple intracranial and spinal lesions: case report.

机构信息

Department of Pediatrics, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10021, USA.

出版信息

Neurosurgery. 2011 Apr;68(4):E1148-51; discussion E1151. doi: 10.1227/NEU.0b013e31820a1573.

Abstract

BACKGROUND AND IMPORTANCE

Solitary fibrous tumor (SFT) has been previously reported for its wide variety of presentations and atypical sites. We report a case of recurrent SFT with multiple intracranial and spinal lesions.

CLINICAL PRESENTATION

A 45-year-old female with recurrent right frontoparietal SFT was found to have multiple intracranial and spinal lesions. Most of the lesions are asymptomatic. Each of the intracranial and spinal lesions has been confirmed histologically. In 1999 the patient was found to have a single right temporal SFT and had a gross total resection of the lesion. In 2005 the patient underwent a second gross total resection for the recurrence of the right temporal-parietal lesion, followed by radiation therapy. In 2009 she underwent a third and fourth gross total resection of the right frontoparietal lesion, and the L4-5 mass, as well as a cervical laminectomy for an extramedullary spinal lesion causing spinal compression.

CONCLUSION

This is the first case report of recurrent SFT with multiple intracranial and spinal lesions. This case illustrates the nature of recurrence and multiplicity of SFT and raises the importance of a thorough investigation, especially in the entire neuroaxis, in patients with the diagnosis of SFT. This case also questions the justification of the name that was given to this tumor.

摘要

背景和重要性

孤立性纤维瘤(SFT)以前因其表现形式多样和发生部位不典型而被报道。我们报告了一例复发性 SFT 伴多发颅内和脊髓病变。

临床特征

一名 45 岁女性,因复发性右侧额顶 SFT 发现多个颅内和脊髓病变。大多数病变无症状。颅内和脊髓的每个病变均经组织学证实。1999 年,该患者发现单个右侧颞部 SFT,行病变大体全切除。2005 年,因右侧颞顶病变复发行第二次大体全切除,随后行放疗。2009 年,她行第三次和第四次右侧额顶病变大体全切除,以及 L4-5 肿块切除术,以及颈椎椎板切除术治疗引起脊髓压迫的髓外脊髓病变。

结论

这是首例复发性 SFT 伴多发颅内和脊髓病变的病例报告。该病例说明了 SFT 复发和多发性的性质,并强调了对诊断为 SFT 的患者进行彻底检查的重要性,特别是对整个神经轴进行检查。该病例还对该肿瘤名称的合理性提出了质疑。

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