Orbital Centre, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
Ophthalmic Plast Reconstr Surg. 2011 Jul-Aug;27(4):236-40. doi: 10.1097/IOP.0b013e31820365d5.
To investigate CT densities of orbital soft tissue volumes in patients with Graves orbitopathy (GO) and to compare these with the densities of controls.
Observational case series. Of 95 patients with GO and 150 controls, soft tissue volumes, mean densities, and ratios of fat volume to orbital volume and muscle volume to orbital volume were calculated with software. The 95% confidence intervals of the controls were used as reference values. The densities were plotted against age and volume ratios. For statistical analysis SPSS 16.00.2 was used. p values were calculated with the following tests: analysis of variance, Pearson correlation, Kruskal-Wallis, Mann-Whitney, and linear regression.
The main outcome measurements were differences in orbital soft tissue densities. In GO patients the mean orbital fat density was significantly higher than in controls (p ≤ 0.001) and independent of age (p = 0.23). The mean extraocular muscle density of GO patients was within the range of controls and did not decrease with age (p = 0.16) as it did in controls (p ≤ 0.001). Mean fat density increased with decreasing fat volume (p = 0.001). Mean extraocular muscle density increased slightly with increasing muscle volume (p = 0.09). Muscle density correlated with fat density in both controls and GO patients.
Orbital fat density in GO patients is significantly higher than in controls and negatively correlated to fat volume but positively correlated to muscle volume and muscle density.
研究格雷夫斯眼病（GO）患者眼眶软组织体积的 CT 密度，并将其与对照组进行比较。
观察性病例系列研究。对 95 例 GO 患者和 150 例对照组患者的软组织体积、平均密度以及脂肪体积与眼眶体积比和肌肉体积与眼眶体积比进行了计算。使用软件计算了对照组的 95%置信区间作为参考值。将密度与年龄和体积比进行了绘制。使用 SPSS 16.00.2 进行统计分析。使用以下测试计算了 p 值：方差分析、Pearson 相关、Kruskal-Wallis、Mann-Whitney 和线性回归。
主要的测量结果是眼眶软组织密度的差异。GO 患者的眼眶脂肪平均密度明显高于对照组（p ≤ 0.001），且与年龄无关（p = 0.23）。GO 患者的眼外肌平均密度在对照组范围内，且不会随着年龄的增长而降低（p = 0.16），而对照组则会降低（p ≤ 0.001）。脂肪平均密度随脂肪体积的减少而增加（p = 0.001）。眼外肌平均密度随肌肉体积的增加而略有增加（p = 0.09）。肌肉密度与对照组和 GO 患者的脂肪密度均呈正相关。
GO 患者的眼眶脂肪密度明显高于对照组，与脂肪体积呈负相关，与肌肉体积和肌肉密度呈正相关。
