Tan S H, Lee B W, Uma R, Aw S E, Tay S H
Department of Paediatrics, National University of Singapore.
J Singapore Paediatr Soc. 1990;32(1-2):27-31.
Non-toxic goitres are commonly encountered in clinical practice, but in the majority the aetiology is unknown. Possible aetiological factors include iodine deficiency, biosynthesis defects, immunologic factors or goitrogens. The consequential effect on thyroid function may be clinically undetectable. In this study, serum thyrotrophin (TSH) response to thyrotrophin-releasing hormone (TRH) stimulation was studied in a group of school children with non-toxic goitres to delineate those who may benefit from treatment. Evaluation of possible aetiological factors responsible for goitrogenesis was made by assessment of thyroid autoantibodies and history of exposure to goitrogens.
非毒性甲状腺肿在临床实践中较为常见，但大多数情况下病因不明。可能的病因包括碘缺乏、生物合成缺陷、免疫因素或致甲状腺肿物质。其对甲状腺功能的后续影响在临床上可能无法检测到。在本研究中，对一组患有非毒性甲状腺肿的学童进行了血清促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）刺激的反应研究，以确定哪些人可能从治疗中获益。通过评估甲状腺自身抗体和接触致甲状腺肿物质的病史，对导致甲状腺肿形成的可能病因进行了评估。
