Aguiar Aline de Almeida Xavier, Carvalho André Ferrer, Costa Carlos Mauricio de Castro, Fernandes José Marcelino Aragão, D'Almeida José Artur Costa, Furtado Luís Edmundo Teixeira de Arruda, Cunha Francisco Marcos Bezerra da
São Marcos Hospital, Teresina, PI, Brazil.
Arq Neuropsiquiatr. 2010 Dec;68(6):843-8. doi: 10.1590/s0004-282x2010000600003.
A retrospective chart review was performed on patients diagnosed as having myasthenia gravis in Ceará State, Brazil and who were followed from October 1981 to June 2009. Clinical and epidemiologic aspects were evaluated. In this work, 122 patients were studied, of whom 85 (69.7%) were females and 37 (30.3%) were males. The disease duration ranged from five months to 50 years (8.9±8.1 years). Age at the first symptoms varied from 0 to 74 years (31.9±14.4 years). The first main symptoms and signs were ptosis, diplopia and limb weakness. Generalized myasthenia was the most common clinical presentation, but 5.1% (n=6) persisted as ocular myasthenia. Thymectomy was performed in 42.6% (n=52) of myasthenic patients. A thymoma was present in 10 patients. Serum acetylcholine receptor (AChR) antibodies were present in 80% (n=20) of specimens tested. The data presented are similar to those of studies performed in other countries.
对巴西塞阿拉州诊断为重症肌无力且在1981年10月至2009年6月期间接受随访的患者进行了回顾性病历审查。评估了临床和流行病学方面。在这项研究中，共研究了122例患者，其中85例（69.7%）为女性，37例（30.3%）为男性。病程从5个月到50年不等（8.9±8.1年）。首次出现症状时的年龄从0岁到74岁不等（31.9±14.4岁）。最初的主要症状和体征为上睑下垂、复视和肢体无力。全身型重症肌无力是最常见的临床表现，但5.1%（n = 6）持续为眼肌型重症肌无力。42.6%（n = 52）的重症肌无力患者接受了胸腺切除术。10例患者存在胸腺瘤。检测的标本中80%（n = 20）存在血清乙酰胆碱受体（AChR）抗体。所呈现的数据与其他国家进行的研究数据相似。
