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老年起病的重症肌无力

Myasthenia Gravis with Elderly Onset at Advanced Age.

作者信息

Hernandez Fustes Otto Jesus, Arteaga Rodriguez Carlos, Hernandez Fustes Olga Judith

机构信息

Neurology, Complexo Hospital de Clínicas - Universidade Federal do Paraná (CHC- UFPR), Curitiba, BRA.

Neurology, Universidade Positivo, Curitiba, BRA.

出版信息

Cureus. 2020 Jan 29;12(1):e6808. doi: 10.7759/cureus.6808.

DOI:10.7759/cureus.6808
PMID:32038895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6991148/
Abstract

Myasthenia gravis (MG) in older adults has not been extensively studied. The prevalence of this disease in older people seems to be higher in recent epidemiological studies. In patients with disease onset after the age of 70, the diagnosis is more difficult as other conditions are more easily taken to be the causal element. The mortality is higher than in young patients, so prompt specific treatment can improve prognosis. We present an 85-year-old female patient with speech disturbance and difficulty in swallowing solids, and neurological examination with palpebral ptosis, disphonia, convergent strabismus and weakness and mild progressive fatigue in arms, with electroneuromyography and acetylcholine receptor antibody who was diagnosed with MG, emphasizing the importance of this entity in geriatric patients.

摘要

老年重症肌无力(MG)尚未得到广泛研究。在最近的流行病学研究中,这种疾病在老年人中的患病率似乎更高。在70岁以后发病的患者中,诊断更为困难,因为其他病症更容易被视为病因。其死亡率高于年轻患者,因此及时进行特异性治疗可改善预后。我们报告了一名85岁女性患者,有言语障碍和吞咽固体食物困难,神经系统检查发现有眼睑下垂、发音障碍、会聚性斜视以及手臂无力和轻度进行性疲劳,通过神经电生理检查和乙酰胆碱受体抗体检测被诊断为MG,强调了该疾病在老年患者中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efe5/6991148/2a300c29b0ee/cureus-0012-00000006808-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efe5/6991148/66b12de76ca6/cureus-0012-00000006808-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efe5/6991148/2a300c29b0ee/cureus-0012-00000006808-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efe5/6991148/66b12de76ca6/cureus-0012-00000006808-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efe5/6991148/2a300c29b0ee/cureus-0012-00000006808-i02.jpg

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本文引用的文献

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Celebrating the 70 years of pyridostigmine on therapy of Myasthenia Gravis: historical aspects of the preliminary trials.庆祝吡啶斯的明治疗重症肌无力70周年:初步试验的历史回顾
Arq Neuropsiquiatr. 2020 Mar;78(3):179-181. doi: 10.1590/0004-282X20190189. Epub 2020 Mar 16.
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The Epidemiology of Myasthenia Gravis in Korea.韩国重症肌无力的流行病学
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Myasthenia gravis: subgroup classification and therapeutic strategies.重症肌无力:亚组分类与治疗策略。
利用自然语言处理技术从神经科医生的临床记录中描述重症肌无力的症状、病情加重及危象
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