Stice Eric, Yokum Sonja, Zald David, Dagher Alain
Oregon Research Institute, Eugene, OR, USA.
Curr Top Behav Neurosci. 2011;6:81-93. doi: 10.1007/7854_2010_89.
Data suggest that low levels of dopamine D2 receptors and attenuated responsivity of dopamine-target regions to food intake is associated with increased eating and elevated weight. There is also growing (although mixed) evidence that genotypes that appear to lead to reduced dopamine signaling (e.g., DRD2, DRD4, and DAT) and certain appetite-related hormones and peptides (e.g., ghrelin, orexin A, leptin) moderate the relation between dopamine signaling, overeating, and obesity. This chapter reviews findings from studies that have investigated the relation between dopamine functioning and food intake and how certain genotypes and appetite-related hormones and peptides affect this relation.
数据表明，多巴胺D2受体水平较低以及多巴胺靶区域对食物摄入的反应性减弱与进食增加和体重上升有关。也有越来越多（尽管参差不齐）的证据表明，那些似乎导致多巴胺信号传导减弱的基因型（例如DRD2、DRD4和DAT）以及某些与食欲相关的激素和肽（例如胃饥饿素、食欲素A、瘦素）会调节多巴胺信号传导、暴饮暴食和肥胖之间的关系。本章回顾了相关研究的结果，这些研究调查了多巴胺功能与食物摄入之间的关系，以及某些基因型和与食欲相关的激素和肽如何影响这种关系。
