Molecular, Cellular and Developmental Biology Graduate Program, The University of Michigan, Ann Arbor, USA; Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, USA.
Molecular, Cellular and Developmental Biology Graduate Program, The University of Michigan, Ann Arbor, USA; Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, USA.
Neurochem Int. 2021 Oct;149:105099. doi: 10.1016/j.neuint.2021.105099. Epub 2021 Jun 13.
Humans have known for millennia that nutrition has a profound influence on health and disease, but it is only recently that we have begun mapping the mechanisms via which the dietary environment impacts brain physiology and behavior. Here we review recent evidence on the effects of energy-dense and methionine diets on neural epigenetic marks, gene expression, and behavior in invertebrate and vertebrate model organisms. We also discuss limitations, open questions, and future directions in the emerging field of the neuroepigenetics of nutrition.
人类几千年来都知道营养对健康和疾病有着深远的影响,但直到最近我们才开始研究饮食环境影响大脑生理和行为的机制。在这里,我们回顾了最近关于高热量和蛋氨酸饮食对无脊椎动物和脊椎动物模型生物的神经表观遗传标记、基因表达和行为影响的证据。我们还讨论了营养神经表观遗传学这一新兴领域的局限性、开放性问题和未来方向。