College of Pharmacy, Chungnam National University, Daejeon, Korea.
Planta Med. 2011 Jun;77(9):955-7. doi: 10.1055/s-0030-1250665. Epub 2011 Jan 17.
Three new sesquiterpene lactones, 1 α,10 β-epoxy-4-hydroxy-glechoma-5-en-olide (1), 1 β,10 α-epoxy-4,8-dihydroxy-glechoma-5-en-olide (2), and 1 β,10 α;4 α,5 β-diepoxy-8-methoxy-glechoman-8 α,12-olide (3), were isolated from the whole plant of Glechoma hederacea, together with four known sesquiterpene lactones. The structures of the three new sesquiterpene lactones were determined by spectroscopic evidence. Cytotoxic effects of the isolated compounds were examined against MDA-MB-231 (breast), HCT116 (colon), SW620 (colon), and DU145 (prostate) human cancer cell lines.
1α,10β-环氧-4-羟基筋骨草-5-烯内酯（1）、1β,10α-环氧-4,8-二羟基筋骨草-5-烯内酯（2）和 1β,10α;4α,5β-环氧-8-甲氧基筋骨草-8α,12-内酯（3），同时还分离得到了四个已知的倍半萜内酯化合物。通过波谱数据确定了这三个新的倍半萜内酯化合物的结构。对分离得到的化合物进行了 MDA-MB-231（乳腺）、HCT116（结肠）、SW620（结肠）和 DU145（前列腺）人癌细胞系的细胞毒性实验。
