[精子形态对体外受精-胚胎移植结局及新生儿状况的影响]

[Influence of sperm morphology on the outcomes and neonatal status in IVF-ET].

作者信息

Shu Jin-Hui, Zhang Bo, Feng Gui-Xue, Gan Xian-You, Zhou Hong, Zhou Li, Liu Yin

机构信息

Reproductive Medicine Center, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530003, China.

出版信息

Zhonghua Nan Ke Xue. 2010 Oct;16(10):897-900.

PMID:21243752

Abstract

OBJECTIVE

To determine the influence of sperm morphology on the outcomes and status of the neonates in in vitro fertilization and embryo transfer (IVF-ET).

METHODS

Strictly based on the WHO criteria, we divided semen samples into a moderately abnormal group (sperm of normal morphology 5% - 10%), a mildly abnormal group (10% < sperm of normal morphology < 15%) and a normal group (sperm of normal morphology > or = 15%) , and compared the rates of fertilization, cleavage, quality embryos, implantation, clinical pregnancy and live births among the three groups.

RESULTS

There were not significant differences in the patients' age among the three groups (P > 0.05). The fertilization rate was markedly lower in the moderately abnormal than in the mildly abnormal group (63.70% vs 73.74%, P < 0.05), but not significantly different from the normal group (63.70% vs 68.05%, P > 0.05). The rate of quality embryos of the normal group was the highest, significantly higher than that of the moderately abnormal group (44.83% vs 35.75%, P < 0.05), but no statistically significant differences were observed in the rates of cleavage, implantation and clinical pregnancy among the three groups (P > 0.05). A total of 125 babies were born from the 280 ET cycles, including 73 singletons and 26 twins, of whom none showed any congenital birth defects. No statistically significant differences were found in the rates of abortion, ectopic pregnancy and premature delivery, nor in the mean gestational period and average body weight of the neonates among the three groups (P > 0.05).

CONCLUSION

Moderately abnormal sperm morphology did not affect the fertility rate of IVF, but significantly decreased the quality of embryos; mildly abnormal sperm morphology had no obvious influence on the rates of fertilization, cleavage, quality embryos, implantation, clinical pregnancy and live births; while normal sperm morphology played a limited role in predicting the outcomes and status of the neonates in IVF-ET.

摘要

目的

确定精子形态对体外受精-胚胎移植（IVF-ET）中新生儿结局及状况的影响。

方法

严格依据世界卫生组织标准，将精液样本分为中度异常组（正常形态精子5% - 10%）、轻度异常组（10%＜正常形态精子＜15%）和正常组（正常形态精子≥15%），比较三组的受精率、卵裂率、优质胚胎率、着床率、临床妊娠率及活产率。

结果

三组患者年龄差异无统计学意义（P＞0.05）。中度异常组受精率显著低于轻度异常组（63.70%对73.74%，P＜0.05），但与正常组差异无统计学意义（63.70%对68.05%，P＞0.05）。正常组优质胚胎率最高，显著高于中度异常组（44.83%对35.75%，P＜0.05），但三组卵裂率、着床率及临床妊娠率差异无统计学意义（P＞0.05）。280个胚胎移植周期中共出生125名婴儿，其中73名单胎、26对双胞胎，无一例有先天性出生缺陷。三组流产率、异位妊娠率及早产率差异无统计学意义，新生儿平均孕周及平均体重差异亦无统计学意义（P＞0.05）。