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评估男性包皮环切术对预防艾滋病毒感染和性传播疾病的保护作用:来自撒哈拉以南非洲18项人口与健康调查的证据。

Assessment of the protective effect of male circumcision from HIV infection and sexually transmitted diseases: evidence from 18 demographic and health surveys in sub-Saharan Africa.

作者信息

Gebremedhin Samson

机构信息

Hawassa University, P.O. Box 12485, Addis Ababa, Ethiopia.

出版信息

Afr J Reprod Health. 2010 Jun;14(2):105-13.

Abstract

A cross-sectional study based on the secondary data of 18 Demographic Health Surveys carried out in Sub-Saharan Africa was conducted to assess the protective effect of male circumcision from HIV infection and STDs. Information on 70,554 males aged 15-59 years was extracted. The association between circumcision and HIV infection and STD symptoms (Genital discharge or ulcer/sore) was assessed using logistic regression. Un-circumcision was significantly associated with risk of HIV with odds ratio of 4.12 (95%CI: 3.85-4.42). The association was even more significant, 4.95 (95%CI: 4.57-5.36), after adjustment was made for number lifetime sexual partners and socio-demographic variables. The risk associated with un-circumcision is significantly lower among younger men aged 15-29 years than older age categories. However, circumcision found to have no association with the symptoms of STDs. The study concluded that male circumcision can be considered as a way of reducing the spread of HIV infection.

摘要

基于在撒哈拉以南非洲地区开展的18次人口健康调查的二手数据进行了一项横断面研究,以评估男性包皮环切术对预防艾滋病毒感染和性传播疾病的保护作用。提取了70554名年龄在15至59岁之间男性的信息。使用逻辑回归分析评估包皮环切术与艾滋病毒感染及性传播疾病症状(生殖器分泌物或溃疡/疮)之间的关联。未行包皮环切术与感染艾滋病毒的风险显著相关,比值比为4.12(95%置信区间:3.85 - 4.42)。在对终身性伴侣数量和社会人口学变量进行调整后,这种关联更为显著,比值比为4.95(95%置信区间:4.57 - 5.36)。在15至29岁的年轻男性中,未行包皮环切术相关的风险显著低于其他年龄组。然而,发现包皮环切术与性传播疾病症状无关联。该研究得出结论,男性包皮环切术可被视为减少艾滋病毒感染传播的一种方式。

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