University of Ottawa Heart Institute, Division of Cardiology, Ottawa, Ontario K1Y 4E9, Canada.
Trends Cardiovasc Med. 1994 Jul-Aug;4(4):169-78. doi: 10.1016/1050-1738(94)90054-X.
Restenosis commonly occurs after coronary interventional procedures, and is largely thought to be a problem of uncontrolled cellular proliferation. Unfortunately, the clinical study of lumen renarrowing is unable to confirm this, as arteriography only provides information about changes in vessel lumen dimension and not wall mass. Recently, we found cell proliferation to be a modest and infrequent event in restenotic coronary atherectomy specimens and have come to question existing concepts of the pathophysiology of restenosis. This review highlights alternate biological and clinical processes that may be important for the understanding of this clinical conundrum.
血管介入术后常发生再狭窄，普遍认为这是一个细胞失控性增殖的问题。遗憾的是，管腔狭窄的临床研究无法证实这一点，因为血管造影术仅提供有关血管腔尺寸变化的信息，而不提供管壁质量的信息。最近，我们发现，细胞增殖在再狭窄的经皮冠状动脉腔内斑块旋切术标本中只是一个轻微和不常见的事件，这使我们对再狭窄的病理生理学的现有概念产生了质疑。本综述强调了可能对理解这一临床难题具有重要意义的替代生物学和临床过程。
