Schillinger Martin, Minar Erich
Department of Angiology, University of Vienna Medical School, Vienna, Austria.
Vasc Health Risk Manag. 2005;1(1):73-8. doi: 10.2147/vhrm.1.1.73.58932.
Restenosis after endovascular treatment of atherosclerotic lesions in the peripheral, cerebrovascular, and coronary circulation is the major drawback of this minimally invasive technique. Although certain advances have been made during recent years to improve patency rates after percutaneous angioplasty, restenosis remains a challenging clinical problem. Understanding factors that contribute to the pathophysiology of late lumen loss is an effective strategy to improving patients' postangioplasty outcome. Vascular inflammation after balloon angioplasty or stent implantation has been identified as a cornerstone of the restenotic process, and several markers of inflammation have been referred to as potential predictors of outcome. This article reviews recent findings on the issue of inflammation and restenosis after percutaneous angioplasty with special attention given to the role of inflammatory parameters as markers for the restenosis risk in the peripheral vessel area.
外周、脑血管和冠状动脉循环中动脉粥样硬化病变血管内治疗后的再狭窄是这种微创技术的主要缺点。尽管近年来为提高经皮血管成形术后的通畅率取得了一定进展，但再狭窄仍然是一个具有挑战性的临床问题。了解导致晚期管腔丢失病理生理学的因素是改善患者血管成形术后预后的有效策略。球囊血管成形术或支架植入术后的血管炎症已被确定为再狭窄过程的基石，几种炎症标志物被认为是预后的潜在预测指标。本文综述了经皮血管成形术后炎症与再狭窄问题的最新研究结果，特别关注炎症参数在外周血管区域作为再狭窄风险标志物的作用。
